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. 2021 Sep 6;2021(9):CD011556. doi: 10.1002/14651858.CD011556.pub2

Summary of findings 4. Tailored print materials in addition to standard smoking cessation treatment in primary care.

Tailored print materials in addition to standard smoking cessation treatment in primary care
Patient or population: people who attend primary care and smoke tobacco
Setting: primary care (Europe)
Intervention: tailored print materials plus standard smoking cessation support
Comparison: standard smoking cessation support
Outcomes Anticipated absolute effects* (95% CI) Relative effect
(95% CI) № of participants
(studies) Certainty of the evidence
(GRADE) Comments
Risk with placebo Risk with tailored print materials
Smoking abstinence at 6‐month follow‐up or more Study population RR 1.29
(1.04 to 1.59) 15,978
(6 RCTs) ⊕⊕⊕⊝
MODERATEa
3 per 100 4 per 100
(4 to 5)
*The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).

CI: Confidence interval; RCT: randomized controlled trial; RR: Risk ratio
GRADE Working Group grades of evidenceHigh certainty: We are very confident that the true effect lies close to that of the estimate of the effect
Moderate certainty: We are moderately confident in the effect estimate: The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different
Low certainty: Our confidence in the effect estimate is limited: The true effect may be substantially different from the estimate of the effect
Very low certainty: We have very little confidence in the effect estimate: The true effect is likely to be substantially different from the estimate of effect

aDowngraded one level due to risk of bias. Removing the two studies judged to be at high risk of bias shifted the CI so that it incorporated the potential for no difference in cessation rates between intervention and comparator groups.