Sanz‐Pozo 2006.

Study characteristics
Methods	Design: Randomized controlled trial Setting: Primary care clinic, Spain Recruitment: GPs recruited patients in practice
Participants	125 people who smoked daily, attending clinic, motivated to make a quit attempt but not interested in using pharmacotherapy, av.age ~ 40, av.cpd 19, 52% F (intervention), 62% F (control)
Interventions	Intervention: participants received brief advice from their doctor at recruitment, an appointment with clinic nurse 7 days before TQD, on TQD, 1w, 1m, 2m, 3m. Control: participants received brief advice only
Outcomes	12m sustained abstinence at 24m Validation: Expired CO < 8 ppm
Funding Source	Not reported
Author's declarations of interest	Not reported
Notes	Strategy: Adjunctive counseling Level: Patient Comparison type: Single component
Risk of bias
Bias	Authors' judgement	Support for judgement
Sequence Generation	Unclear risk	QUOTE: "the patients recruited were randomised, according to the clinic from which they came, to the group that received...". No further detail.
Allocation concealment	Unclear risk	No details reported
Blinding of outcome assessors All outcomes	Low risk	Smoking abstinence was biochemically validated
Incomplete outcome data All outcomes	High risk	The overall loss to follow‐up was 42.4% (n = 53/125); 75% (n = 45/60) in the intervention group and 12.3% (n = 8/65) in the control group were lost to follow‐up at 2 years