Study	Reason for exclusion
Adair 2013	Addressed multiple risk factors. No specific intervention strategy for smoking cessation
Adam 2019	Outcomes: Cessation not reported
Agarwal 2018	Cessation outcome not reported. (Main outcome: quit attempts)
An 2008	Follow‐up < 6 months
Andrews 2001	Cessation outcome not reported.
Aveyard 2007	Compares 2 active interventions ‐ unable to isolate a single component
Bachmann 2019	Outcomes: Cessation not reported
Bakkevig 2000	Intervention not conducted in primary care
Bentz 2007	Follow‐up < 6 months
Bosworth 2008	Outcomes of interest not reported (Main outcome: Medication adherence and improvement of hypertension‐related health behaviors)
Burke 1993	Only evaluated the efficacy of pharmacotherapy
Butler 1999	Counseling performed by general practitioners
Carey 2016	Follow‐up < 6 months
Cheung 2019	Intervention not conducted in primary care
Cockburn 1992	Intervention relates to marketing strategies for smoking cessation programs
Cohen 2011	Outcomes of interest not reported (Main outcome: Change in proportion of participants achieving target glycemic and cardiac risk factor goals)
Coma 2019	Outcomes: Cessation not reported
Conger 1987	Only intervention was advice from GPs
de Ruijter 2018	Did not assess smoking cessation
Dey 1999	Follow‐up < 6 months
Dickinson 2013	Addressed multiple risk factors. Tobacco users could choose to not participate in the smoking cessation part of the intervention
Dignan 2019	Intervention not conducted in primary care
Drexel 2011	Outcomes of interest not reported (Main outcome: Provision of evidence based COPD care)
Dubey 2006	Follow‐up < 6 months
Efraimsson 2008	Follow‐up l< 6 months
Eikelenboom 2013	Addressed multiple risk factors. No specific intervention strategy for smoking cessation
Emery 2019	No specific intervention strategy for smoking cessation
Emmons 2014	Outcomes of interest not reported (Main outcome: Multiple risk behavior score)
Engle 2019	Intervention tests only simple counseling and medication
Escortell‐Mayor 2020	Multiple risk factor study
Etter 2000	Follow‐up < 6 months
Felton 2019	Outcomes: Cessation not reported
Ferketich 2014	Follow‐up < 6 months
Ferrer 2009	Multiple risk factor study
Fiore 2019	Does not report on a cessation outcome.
Flocke 2014	Follow‐up < 6 months
Folz 2016	Smoking was a secondary outcome and very few people who smoked were involved ‐ 9 in intervention group and 1 in control group
Frank 2004	Follow‐up < 6 months
Fu 2015	Outcomes of interest not reported (Main outcome: Perceived skill in use of 5As and confidence in addressing smoking cessation)
Fulton 2019	Intervention not conducted in primary care
Gerbert 2003	Outcomes of interest not reported (Main outcome: Acceptability of video‐doctor program)
Gilbert 1989	GP delivered counseling. NRT was not cost‐free.
Gilbert 1992	GP delivered follow‐up counseling compared to no follow‐up does not meet our criteria for adjunctive counseling
Gilbert 2007	Follow‐up < 6 months
Gilbody 2019	Intervention tests simple counseling and medication.
Godycki‐Cwirko 2014	Addressed multiple risk factors. No specific intervention strategy for smoking cessation
Green 2020	Does not report on a cessation outcome
Grischott 2019	Tests simple counseling intervention
Groner 2000	The participants of the study were not patients of the general practitioner, but rather the people accompanying the patient
Hall 2003	Outcomes of interest not reported (Main outcome: Readiness to quit)
Harding 2019	Does not report on a cessation outcome
Haug 1994	Only brief advice intervention
Houston 2015	Compares 2 active interventions ‐ unable to isolate a single component
Hughes 1981	Not conducted in primary care
Humphris 2004	Outcomes of interest not reported (Main outcome: Knowledge of oral cancer)
Imperial Cancer Research Fund GP Research Group	Only evaluated the efficacy of pharmacotherapy
Javitz 2004	Compares 2 active interventions ‐ unable to isolate a single component
Jennings 2014	Follow‐up < 6 months
Jolly 2017	Not a smoking cessation intervention
Kalkhoran 2016	Cessation outcome not reported
Kalkhoran 2019	Counseling intervention tested, but no cluster randomization
Kamstrup‐Larsen 2019	Tests simple counseling intervention only.
Karner 2012	No smoking cessation intervention tested
Kastaun 2021	Compared 2 types of health provider training head to head. Did not allow for separation of effect of provider training
Kennedy 2019	Not a smoking cessation intervention
Kim 2020	Does not report on a cessation outcome
Kirkman 1994	Multiple risk factor study
Knight 1989	Outcomes of interest not reported (Main outcome: Predictors of quitting smoking)
Krones 2010	Outcomes of interest not reported (Main outcome: Validity of the Theory of Planned Behavior in a decision aid)
Kruse 2020	Follow‐up < 6 months
Lasser 2013	Outcomes of interest not reported (Main outcome: Engagement in smoking cessation treatment)
Leung 2019	Tests simple pharmacotherapy only.
Liang 2019	Tests simple counseling intervention only
Liebmann 2019	Adjunctive counseling intervention tests but not cluster‐randomized
Linder 2009	Follow‐up < 6 months
Lycett 2010	All participants had identical treatment to stop smoking
Machline‐Carrion 2019	Does not include a cessation outcome.
Mahapatra 2019	Not an RCT
Markun 2018	Smoking cessation was never an intended outcome
McAlister 2009	Multiple risk factor study
McEwen 2002	Follow‐up < 6 months
McGrath 2014	Follow‐up < 6 months
McPhee 1991	Cessation outcome not reported.
McRee 2005	Cessation outcome not reported. Main outcome:
McRobbie 2008	Follow‐up < 6 months
Mehring 2014	Follow‐up < 6 months
Minian 2019	Not a smoking cessation intervention
Muckelbauer 2015	Multiple risk factor study
Naughton 2014	Compares 2 active interventions ‐ unable to isolate a single component
NCT01072422	follow‐up < 6 months
NCT03221010	follow‐up < 6 months
NCT04200534	Cessation measured < 6 months
NCT04316260	Cessation measured < 6 months
Neuner‐Jehle 2013	Cessation outcome not reported.
Nilsson 1996	Follow‐up < 6 months
Ojedokun 2013	Follow‐up < 6 months
Papadakis 2013	Follow‐up < 6 months
Parchman 2019	Multiple risk factor study
Peckham 2019	Not conducted in primary care
Peprah 2019	Multiple risk factor study
Persai 2020	Does not report on a cessation outcome
Persell 2013	Outcomes of interest not reported (Main outcome: LDL Cholesterol levels)
Pieterse 2001	GP delivered counseling
Piper 2003	Pre‐post evaluation, not an RCT study design
Prabhakaran 2019	No smoking cessation intervention tested
Prochaska 2005	Multiple risk factor study
Prokhorov 2010	Follow‐up < 6 months
Redfern 2014a	Addressed multiple risk factors. No specific intervention strategy for smoking cessation
Richmond 1985	GP delivered counseling.
Richmond 1998	Cessation outcome not reported.
Richter 2015	Compares 2 active interventions ‐ unable to isolate a single component
Rigotti 2011	Follow‐up < 6 months
Robson 1989	Follow‐up < 6 months
Rodriguez Alverez 2008	Compares 2 active interventions ‐ unable to isolate a single component
Roski 1998	Cessation outcome not reported.
Rosser 1992	Follow‐up < 6 months
Rothemich 2008	Follow‐up < 6 months
Rothemich 2010	Follow‐up < 6 months
Sanders 1989	Only brief advice intervention
Satterfield 2018	Follow‐up < 6 months, cessation outcome not reported
Schwartz 2015	Multiple risk factor study
Sejourne 2010	Outcomes of interest not reported (Main outcome: Readiness to quit)
Senesael 2013	Addressed multiple risk factors. No specific intervention strategy for smoking cessation
Shaughnessy 1987	Couseling only on use of medications
Sheffer 2012	Cessation outcome not reported.
Shelley 2016	Did not set out to measure smoking abstinence
Sherman 2017	Compares 2 active interventions ‐ unable to isolate a single component
Silveira 2019	Simple counseling intervention tested only
Silverman 2004	Cessation outcome not reported.
Slama 1990	GP delivered counseling
Smit 2010	Deviated from protocol, not set in primary care
Sperl‐Hillen 2018	Multiple risk factor study
Stratelis 2006	Compares 2 active interventions ‐ unable to isolate a single component
Strecher 1994	Follow‐up < 6 months
Taylor 2019	Did not occur in primary care
Thompson 1988	GP delivered counseling
Thompson 2015	Follow‐up < 6 months
Valdivieso‐Lopez 2013	Study population is pregnant women
Velasquez 2014	Study population is pregnant women
Vidrine 2013	Follow‐up < 6 months
Vogt 2009	Does not report on abstinence outcome.
Voogdt‐Pruis 2011	Outcomes of interest not reported (Main outcome: Number of lifestyle and medical interventions)
Vorderstrasse 2013	Not a smoking cessation intervention
Waage 1997	No smoking cessation strategy conducted in primary care
Wadland 2007	Does not report on abstinence outcome.
Weingarten 1989	Follow‐up < 6 months
West 1998	Follow‐up < 6 months
Wilson 1982	GP delivered follow‐up counseling
Woollard 1995	Outcomes of interest not reported (Main outcome: Blood pressure)
Yalcin 2014	Only evaluating different intensities of counseling
Yingst 2018	Follow‐up < 6 months
Young 2002a	Follow‐up < 6 months
Young 2002b	Follow‐up < 6 months
Ziyash 2019	Tests simple counseling intervention only
Zwar 2016	Multiple risk factor study