NCT04199117.

Study name	Centralized health system interventions to enhance reach: a factorial screening experiment
Methods	Randomized factorial experiment
Participants	Adult primary care patients smoked at least 5 cigarettes per day for at least 6 months at enrolment. Able to speak and read English
Interventions	2x2x2x2 factorial experiment: 1. Modest financial incentives (USD 40) for completing an initial counseling session in a smoking cessation treatment (vs. none) 2. Automated semi‐annual outreach materials sent via participants' preferred communication modality using data in the electronic health record to tailor and personalize invitations to use available treatments to quit smoking (vs. untailored letters) 3. Direct, proactive telephone outreach from a tobacco care manager who will promote treatment use and deliver motivational intervention twice per year (vs. none) 4. Access to 3 no‐cost telephone smoking cessation counseling calls with combination nicotine replacement therapy (C‐NRT) or varenicline (vs. state tobacco quitline and primary care provider referral)
Outcomes	7‐day point‐prevalence abstinence at 3w, 3m, 6m, 2y
Starting date	11 March 2020
Contact information	Michael C Fiore mcf@ctri.wisc.edu
Notes	NCT04199117