Summary of findings 5. Erectile function ‐ short term.
Minimally invasive treatments versus transurethral resection of the prostate | ||||
Patient or population: men with moderate to severe lower urinary symptoms due to benign prostatic hyperplasia Interventions: minimally invasive treatments. Comparator (reference): sham procedure or transurethral resection of the prostate Setting: hospital procedure – outpatient follow‐up | ||||
Outcome: erectile function Measured by: IIEF scores range 5‐25 (higher scores indicate better function). Follow‐up 3 to 12 months | ||||
6 studies 640 participants |
Anticipated absolute effect (95% CI) * | Certainty of the evidence | Ranking (SUCRA) ** | |
With TURP | With a minimally invasive procedure | |||
CRFWVT (Rezūm) (indirect estimate) |
Mean score in the included studies: 15.16 (range 11.67 to 17.70)a | 6.49 higher (8.13 lower to 21.12 higher) |
⊕⊝⊝⊝ VERY LOW b c d |
2.5 (70.7%) |
TIND (indirect estimate) |
5.19 higher (9.36 lower to 19.74 higher) |
⊕⊝⊝⊝ VERY LOW b c d |
2.9 (61.7%) |
|
PUL (UroLift) (mixed estimate) |
3.00 higher (5.45 lower to 11.44 higher) |
⊕⊝⊝⊝ VERY LOW b c d |
3.5 (49.5%) |
|
PAE (mixed estimate) |
0.03 lower (6.38 lower to 6.32 higher) |
⊕⊝⊝⊝ VERY LOW b c d |
4.4 (31.1%) |
|
TUMT | Not reported | |||
CI: confidence interval; CRFWVT: convective radiofrequency water vapor therapy; IIEF: International Index of Erectile Function; IPSS: International Prostate Symptom Score; MD: mean difference; PAE: prostatic arterial embolization; PUL: prostatic urethral lift; SUCRA: surface under the cumulative ranking curve; TIND: temporary implantable nitinol device; TUMT: transurethral microwave thermotherapy; TURP: transurethral resection of prostate. Network meta‐analysis summary of findings table definitions: * Estimates are reported as mean difference and confidence interval (CI). ** Rank statistics is defined as the probability that a treatment out of n treatments in a network meta‐analysis is the best, the second, the third, and so on until the least effective treatment. Between brackets are the surface under the curve (SUCRA) estimates. | ||||
GRADE Working Group grades of evidence (or certainty of the evidence). High certainty: we are very confident that the true effect lies close to that of the estimate of the effect. Moderate certainty: we are moderately confident in the effect estimate: the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different. Low certainty: our confidence in the effect estimate is limited: the true effect may be substantially different from the estimate of the effect. Very low certainty: we have very little confidence in the effect estimate: the true effect is likely to be substantially different from the estimate of effect. |
aTURP was the lowest‐ranked intervention for this outcome with a mean rank of 4.6 (SUCRA 27.2%)
bDowngraded by one level due to major concerns on within‐study bias: nearly all studies contributing to this estimate had an overall high risk of bias.
cDowngraded by one level due to major concerns on imprecision: the estimate crosses the threshold for minimally important difference (five points for IIEF‐5) including substantial benefits and harms.
dDowngraded by one level due to major concerns on incoherence: the network does not present close loops to assess incoherence.