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. 2021 Jul 15;2021(7):CD013656. doi: 10.1002/14651858.CD013656.pub2

Comparison 1. Minimally invasive treatment versus TURP.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1.1 Urologic symptom scores 11   Mean Difference (IV, Random, 95% CI) Subtotals only
1.1.1 PUL 1 76 Mean Difference (IV, Random, 95% CI) ‐0.30 [‐3.90, 3.30]
1.1.2 TUMT 4 304 Mean Difference (IV, Random, 95% CI) 3.44 [‐0.16, 7.05]
1.1.3 PAE 6 369 Mean Difference (IV, Random, 95% CI) 2.42 [0.37, 4.47]
1.2 Urologic symptoms score (long term) 5   Mean Difference (IV, Random, 95% CI) Subtotals only
1.2.1 TUMT 2 126 Mean Difference (IV, Random, 95% CI) 1.45 [‐0.54, 3.44]
1.2.2 PUL 1 69 Mean Difference (IV, Random, 95% CI) 4.80 [1.11, 8.49]
1.2.3 PAE 2 176 Mean Difference (IV, Random, 95% CI) 2.58 [‐1.54, 6.71]
1.3 Quality of life 7   Mean Difference (IV, Random, 95% CI) Subtotals only
1.3.1 PUL 1 125 Mean Difference (IV, Random, 95% CI) 0.40 [‐0.17, 0.97]
1.3.2 TUMT 1 125 Mean Difference (IV, Random, 95% CI) 0.40 [‐0.17, 0.97]
1.3.3 PAE 5 309 Mean Difference (IV, Random, 95% CI) 0.25 [‐0.75, 1.25]
1.4 Quality of life (long term) 4   Mean Difference (IV, Random, 95% CI) Subtotals only
1.4.1 PAE 2 176 Mean Difference (IV, Random, 95% CI) 0.42 [‐0.11, 0.95]
1.4.2 PUL 1 69 Mean Difference (IV, Random, 95% CI) 0.80 [0.07, 1.53]
1.4.3 TUMT 1 97 Mean Difference (IV, Random, 95% CI) 0.00 [‐0.46, 0.46]
1.5 Major adverse events 11   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
1.5.1 PUL 1 79 Risk Ratio (M‐H, Random, 95% CI) 0.27 [0.03, 2.44]
1.5.2 TUMT 6 525 Risk Ratio (M‐H, Random, 95% CI) 0.20 [0.09, 0.43]
1.5.3 PAE 4 301 Risk Ratio (M‐H, Random, 95% CI) 0.67 [0.25, 1.76]
1.6 Retreatment (short term) 2   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
1.6.1 TUMT 1 68 Risk Ratio (M‐H, Random, 95% CI) 1.47 [0.06, 34.66]
1.6.2 PAE 1 60 Risk Ratio (M‐H, Random, 95% CI) 9.76 [0.49, 194.21]
1.7 Retreatment (long term) 8   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
1.7.1 PUL 1 79 Risk Ratio (M‐H, Random, 95% CI) 2.39 [0.51, 11.10]
1.7.2 TUMT 4 395 Risk Ratio (M‐H, Random, 95% CI) 9.71 [2.35, 40.15]
1.7.3 PAE 3 243 Risk Ratio (M‐H, Random, 95% CI) 4.44 [1.24, 15.93]
1.8 Erectile function (short term) 3   Mean Difference (IV, Random, 95% CI) Subtotals only
1.8.1 PUL 1 59 Mean Difference (IV, Random, 95% CI) 3.00 [0.02, 5.98]
1.8.2 PAE 2 129 Mean Difference (IV, Random, 95% CI) ‐0.03 [‐6.35, 6.29]
1.9 Erectile function (long term) 1   Mean Difference (IV, Random, 95% CI) Subtotals only
1.9.1 PUL 1 57 Mean Difference (IV, Random, 95% CI) 1.60 [‐0.80, 4.00]
1.10 Erectile function (short term) 6   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
1.10.1 TUMT 4 278 Risk Ratio (M‐H, Random, 95% CI) 0.79 [0.40, 1.55]
1.10.2 PUL 1 79 Risk Ratio (M‐H, Random, 95% CI) 0.11 [0.01, 2.14]
1.10.3 PAE 1 61 Risk Ratio (M‐H, Random, 95% CI) 0.19 [0.02, 1.56]
1.11 Erectile function (long term) 1   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
1.11.1 TUMT 1 119 Risk Ratio (M‐H, Random, 95% CI) 0.49 [0.17, 1.41]
1.12 Ejaculatory function 1   Mean Difference (IV, Random, 95% CI) Subtotals only
1.12.1 PUL (short term) 1 59 Mean Difference (IV, Random, 95% CI) 6.30 [4.47, 8.13]
1.12.2 PUL (long term) 1 56 Mean Difference (IV, Random, 95% CI) 6.00 [3.89, 8.11]
1.13 Ejaculatory function (short term) 8   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
1.13.1 TUMT 4 241 Risk Ratio (M‐H, Random, 95% CI) 0.36 [0.24, 0.53]
1.13.2 PAE 3 141 Risk Ratio (M‐H, Random, 95% CI) 0.26 [0.06, 1.19]
1.13.3 PUL 1 79 Risk Ratio (M‐H, Random, 95% CI) 0.05 [0.00, 0.90]
1.14 Ejaculatory function (long term) 2   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
1.14.1 TUMT 1 69 Risk Ratio (M‐H, Random, 95% CI) 0.05 [0.00, 0.85]
1.14.2 PAE 1 50 Risk Ratio (M‐H, Random, 95% CI) 0.67 [0.45, 0.98]
1.15 Minor adverse events 8   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
1.15.1 TUMT 4 337 Risk Ratio (M‐H, Random, 95% CI) 1.27 [0.75, 2.15]
1.15.2 PAE 3 197 Risk Ratio (M‐H, Random, 95% CI) 1.26 [0.40, 4.02]
1.15.3 PUL 1 79 Risk Ratio (M‐H, Random, 95% CI) 0.88 [0.70, 1.09]
1.16 Acute urinary retention 10   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
1.16.1 TUMT 4 343 Risk Ratio (M‐H, Random, 95% CI) 2.61 [1.05, 6.47]
1.16.2 PAE 5 367 Risk Ratio (M‐H, Random, 95% CI) 1.79 [0.67, 4.77]
1.16.3 PUL 1 79 Risk Ratio (M‐H, Random, 95% CI) 7.20 [0.40, 129.38]
1.17 Indwelling urinary catheter 1   Mean Difference (IV, Random, 95% CI) Subtotals only
1.17.1 PAE 1 99 Mean Difference (IV, Random, 95% CI) ‐2.00 [‐2.55, ‐1.45]
1.18 Urologic symptom scores (subgroup: age) 11 749 Mean Difference (IV, Random, 95% CI) 2.51 [0.85, 4.18]
1.18.1 Average age < 65 2 100 Mean Difference (IV, Random, 95% CI) 2.37 [1.25, 3.49]
1.18.2 Average age > 65 9 649 Mean Difference (IV, Random, 95% CI) 2.49 [0.19, 4.80]
1.19 Urologic symptom scores (subgroup: severity) 11 749 Mean Difference (IV, Random, 95% CI) 2.51 [0.85, 4.18]
1.19.1 IPSS < 19 2 112 Mean Difference (IV, Random, 95% CI) 4.96 [‐4.74, 14.66]
1.19.2 IPSS > 19 9 637 Mean Difference (IV, Random, 95% CI) 2.17 [0.70, 3.64]