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. 2021 Jul 15;2021(7):CD013656. doi: 10.1002/14651858.CD013656.pub2

Comparison 2. Miminally invasive treatment versus sham.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
2.1 Urologic symptom scores 8   Mean Difference (IV, Random, 95% CI) Subtotals only
2.1.1 PAE 1 80 Mean Difference (IV, Random, 95% CI) ‐12.70 [‐15.69, ‐9.71]
2.1.2 CRFWVT 1 197 Mean Difference (IV, Random, 95% CI) ‐6.70 [‐8.90, ‐4.50]
2.1.3 PUL 1 206 Mean Difference (IV, Random, 95% CI) ‐7.30 [‐9.73, ‐4.87]
2.1.4 TUMT 4 491 Mean Difference (IV, Random, 95% CI) ‐5.47 [‐7.17, ‐3.77]
2.1.5 iTIND 1 124 Mean Difference (IV, Random, 95% CI) ‐2.80 [‐5.98, 0.38]
2.2 Quality of life 6   Mean Difference (IV, Random, 95% CI) Subtotals only
2.2.1 PAE 1 80 Mean Difference (IV, Random, 95% CI) ‐2.05 [‐2.59, ‐1.51]
2.2.2 CRFWVT 1 197 Mean Difference (IV, Random, 95% CI) ‐1.20 [‐1.65, ‐0.75]
2.2.3 PUL 1 206 Mean Difference (IV, Random, 95% CI) ‐1.20 [‐1.68, ‐0.72]
2.2.4 TUMT 2 347 Mean Difference (IV, Random, 95% CI) ‐0.81 [‐1.13, ‐0.49]
2.2.5 iTIND 1 185 Mean Difference (IV, Random, 95% CI) ‐0.70 [‐1.31, ‐0.09]
2.3 Major adverse events 4   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
2.3.1 PAE 1 80 Risk Ratio (M‐H, Random, 95% CI) 3.00 [0.13, 71.51]
2.3.2 CRFWVT 1 197 Risk Ratio (M‐H, Random, 95% CI) 2.26 [0.11, 46.44]
2.3.3 PUL 1 206 Risk Ratio (M‐H, Random, 95% CI) 0.94 [0.09, 10.21]
2.3.4 TIND 1 185 Risk Ratio (M‐H, Random, 95% CI) 3.15 [0.17, 59.95]
2.4 Retreatment (short term) 2   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
2.4.1 CRFWVT 1 197 Risk Ratio (M‐H, Random, 95% CI) 1.36 [0.06, 32.86]
2.4.2 iTIND 1 185 Risk Ratio (M‐H, Random, 95% CI) 0.67 [0.11, 3.89]
2.5 Retreatment (long term) 2   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
2.5.1 TUMT 2 82 Risk Ratio (M‐H, Random, 95% CI) 0.27 [0.08, 0.88]
2.6 Erectile function (IIEF‐5) 3   Mean Difference (IV, Random, 95% CI) Subtotals only
2.6.1 Rezum 1 130 Mean Difference (IV, Random, 95% CI) 1.70 [‐1.61, 5.01]
2.6.2 PUL 1 197 Mean Difference (IV, Random, 95% CI) ‐1.80 [‐4.39, 0.79]
2.6.3 TIND 1 124 Mean Difference (IV, Random, 95% CI) 0.40 [‐2.56, 3.36]
2.7 Erectile function (IIEF) 1   Mean Difference (IV, Random, 95% CI) Subtotals only
2.7.1 PAE 1 80 Mean Difference (IV, Random, 95% CI) 5.70 [‐2.83, 14.23]
2.8 Ejaculatory function 2   Mean Difference (IV, Random, 95% CI) Subtotals only
2.8.1 CRFWVT 1 130 Mean Difference (IV, Random, 95% CI) 0.10 [‐1.52, 1.72]
2.8.2 PUL 1 144 Mean Difference (IV, Random, 95% CI) 0.40 [‐0.77, 1.57]
2.9 Ejaculatory function 1   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
2.9.1 CRFWVT 1 131 Risk Ratio (M‐H, Random, 95% CI) 4.01 [0.22, 72.78]
2.10 Minor adverse events 7   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
2.10.1 PAE 1 80 Risk Ratio (M‐H, Random, 95% CI) 1.08 [0.58, 1.99]
2.10.2 TUMT 3 378 Risk Ratio (M‐H, Random, 95% CI) 1.42 [1.00, 2.01]
2.10.3 PUL 1 206 Risk Ratio (M‐H, Random, 95% CI) 1.69 [1.33, 2.16]
2.10.4 CRFWVT 1 197 Risk Ratio (M‐H, Random, 95% CI) 1.89 [1.15, 3.11]
2.10.5 iTIND 1 185 Risk Ratio (M‐H, Random, 95% CI) 3.56 [1.32, 9.60]
2.11 Acute urinary retention 9   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
2.11.1 TUMT 6 858 Risk Ratio (M‐H, Random, 95% CI) 9.02 [3.31, 24.63]
2.11.2 iTIND 1 185 Risk Ratio (M‐H, Random, 95% CI) 6.74 [0.39, 116.11]
2.11.3 CRFWVT 1 197 Risk Ratio (M‐H, Random, 95% CI) 4.98 [0.28, 88.63]
2.11.4 PUL 1 206 Risk Ratio (M‐H, Random, 95% CI) 0.47 [0.03, 7.42]
2.12 Indwelling urinary catheter 1   Mean Difference (IV, Random, 95% CI) Subtotals only
2.12.1 CRFWVT 1 134 Mean Difference (IV, Random, 95% CI) 2.50 [1.77, 3.23]
2.13 Urologic symptom scores (subgroup: age) 8 1098 Mean Difference (IV, Random, 95% CI) ‐6.55 [‐8.51, ‐4.60]
2.13.1 Average age > 65 4 657 Mean Difference (IV, Random, 95% CI) ‐5.42 [‐6.69, ‐4.14]
2.13.2 Average age < 65 4 441 Mean Difference (IV, Random, 95% CI) ‐7.80 [‐11.74, ‐3.87]
2.14 Quality of life (subgroup: age) 6 1015 Mean Difference (IV, Random, 95% CI) ‐1.12 [‐1.50, ‐0.75]
2.14.1 Average age > 65 3 553 Mean Difference (IV, Random, 95% CI) ‐0.93 [‐1.20, ‐0.65]
2.14.2 Average age < 65 3 462 Mean Difference (IV, Random, 95% CI) ‐1.32 [‐2.05, ‐0.60]