Comparison 3. Multi‐component vs usual care.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
3.1 Multi: exacerbations: number of people experiencing at least 1 exacerbation/moderate to severe exacerbation (52 weeks)	3	955	Odds Ratio (M‐H, Random, 95% CI)	0.98 [0.74, 1.28]
3.2 Multi: exacerbations: time to first exacerbation (hazard ratio)	1		Hazard Ratio (IV, Random, 95% CI)	Totals not selected
3.3 Multi: quality of life: SGRQ total	4		Mean Difference (IV, Random, 95% CI)	Subtotals only
3.3.1 3 to < 6 months	1	38	Mean Difference (IV, Random, 95% CI)	‐9.70 [‐18.32, ‐1.08]
3.3.2 6 to < 12 months	1	40	Mean Difference (IV, Random, 95% CI)	7.00 [‐4.79, 18.79]
3.3.3 ≥ 12 months	2	203	Mean Difference (IV, Random, 95% CI)	‐1.09 [‐6.24, 4.05]
3.4 Multi: quality of life: SGRQ total (GIV)	1		Mean Difference (IV, Random, 95% CI)	Totals not selected
3.4.1 ≥ 12 months	1		Mean Difference (IV, Random, 95% CI)	Totals not selected
3.5 Multi: quality of life: CAT	2	521	Mean Difference (IV, Random, 95% CI)	‐3.93 [‐7.75, ‐0.12]
3.6 Multi: hospital use: number of people who had at least 1 hospital admission (26 or 52 weeks)	2	447	Odds Ratio (M‐H, Random, 95% CI)	0.81 [0.55, 1.18]
3.7 Multi: hospital use: length of stay (mean days)	2	523	Mean Difference (IV, Random, 95% CI)	‐0.66 [‐2.40, 1.08]
3.7.1 6 to < 12 months	2	523	Mean Difference (IV, Random, 95% CI)	‐0.66 [‐2.40, 1.08]
3.8 Multi: hospital use: COPD‐related length of stay (days) (26 weeks)	2	523	Mean Difference (IV, Random, 95% CI)	‐0.47 [‐1.49, 0.55]
3.9 Multi: hospital use: number of people re‐admitted (all‐cause)	3	344	Odds Ratio (M‐H, Random, 95% CI)	0.50 [0.31, 0.81]
3.9.1 3 to < 6 months	1	132	Odds Ratio (M‐H, Random, 95% CI)	0.53 [0.21, 1.37]
3.9.2 6 to < 12 months	1	57	Odds Ratio (M‐H, Random, 95% CI)	0.81 [0.29, 2.30]
3.9.3 ≥ 12 months	1	155	Odds Ratio (M‐H, Random, 95% CI)	0.40 [0.21, 0.78]
3.10 Multi: hospital use: hospital re‐admission (hazard ratio)	3		Hazard Ratio (IV, Random, 95% CI)	0.77 [0.38, 1.57]
3.10.1 3 to < 6 months	1		Hazard Ratio (IV, Random, 95% CI)	0.56 [0.23, 1.36]
3.10.2 6 to < 12 months	1		Hazard Ratio (IV, Random, 95% CI)	2.01 [0.71, 5.69]
3.10.3 ≥ 12 months	1		Hazard Ratio (IV, Random, 95% CI)	0.55 [0.35, 0.86]
3.11 Multi: mortality (all‐cause)	9	1886	Odds Ratio (M‐H, Random, 95% CI)	0.62 [0.39, 1.01]
3.11.1 3 to < 6 months	2	172	Odds Ratio (M‐H, Random, 95% CI)	0.20 [0.01, 4.25]
3.11.2 6 to < 12 months	3	604	Odds Ratio (M‐H, Random, 95% CI)	0.83 [0.46, 1.51]
3.11.3 ≥ 12 months	4	1110	Odds Ratio (M‐H, Random, 95% CI)	0.52 [0.22, 1.22]
3.12 Multi: AE: number of people who had an adverse event (52 weeks) (add to SOF table)	2	485	Odds Ratio (M‐H, Random, 95% CI)	0.91 [0.62, 1.33]
3.13 Multi: A/D: HADS total	2		Mean Difference (IV, Random, 95% CI)	Subtotals only
3.14 HADS‐A and HADS‐D	1		Mean Difference (IV, Random, 95% CI)	Totals not selected
3.14.1 HADS‐A	1		Mean Difference (IV, Random, 95% CI)	Totals not selected
3.14.2 HADS‐D	1		Mean Difference (IV, Random, 95% CI)	Totals not selected
3.15 Multi: satisfaction: client satisfaction questionnaire	1		Mean Difference (IV, Random, 95% CI)	Totals not selected