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. 2021 Aug 10;2021(8):CD010037. doi: 10.1002/14651858.CD010037.pub3

Lyle 1987.

Study characteristics
Methods Randomised, double‐blind, placebo‐controlled trial
The trial was conducted in the United States of America.
Participants Normotensive male participants
Ethnicity: Black (n = 21) and white (n = 54)
Age: 19 to 52 years
Interventions Internvention group: calcium, 1500 mg a day
Control group: placebo
"Participants were randomly assigned within racial groups to either treatment".
Trial duration: 12‐week period
Outcomes Blood pressure
Serum levels of total and ionised calcium
Total inorganic phosphorus
Parathyroid hormone
Overnight urinary electrolyte values
Notes  
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Not described
Allocation concealment (selection bias) Low risk The supplements were strip‐wrapped individually and coded by someone not involved in the research study. The participants did not know which group they were assigned to, and the researcher(s) who collected other information also were not aware of the group assignment. Early analyses were completed prior to revealing the assigned groups as well.
Blinding of participants and personnel (performance bias)
All outcomes Low risk Assignment was double‐blind. "Indistinguishable placebo tablets were composed of microcrystalline methylcellulose and starch".
Blinding of outcome assessment (detection bias)
All outcomes Low risk "Use of a random‐baseline sphygmomanometer and blinded observers to eliminate bias during blood pressure measurement, documentation of nutrient intake other than the supplement, and control for body weight and other possible confounders"
Incomplete outcome data (attrition bias)
All outcomes Low risk All participants randomised were included in the results.
Selective reporting (reporting bias) Low risk All outcomes were reported.
Other bias Low risk The groups were similar at baseline.