Fig. 4.

HX600 reduces ischemic damage and improves motor functions in vivo. Lesion size was measured with MRI imaging 48 h after the ischemic insult. Among the HX600 treated mice it was 21% smaller when compared to mice treated with vehicle. Quantitative analysis (A) and representative MRI-images from mice receiving vehicle (B) and HX600 treatment (C). In Latency to move -test ischemia caused clear deterioration of motor function 1 day after the insult (D). HX600 treatment brought the performance back to the level of sham operated mice. Data presented as mean ± SEM, Unpaired two-tailed T-test (A) and 1-way ANOVA followed by Bonferroni posthoc test (D), A: n = 8 in both groups, B: n = 8 in vehicle treated stroke group, 7 in HX600 treated stroke group and 12 in sham group. *p < 0.05.