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. Author manuscript; available in PMC: 2022 Sep 1.
Published in final edited form as: Curr Atheroscler Rep. 2021 Sep 1;23(11):66. doi: 10.1007/s11883-021-00966-9

Figure 1: Possible Contributors to the Development and Expansion of Clonal Hematopoiesis and Cardiovascular Events.

Figure 1:

Germline genetics confer modestly increased risk of clonal hematopoiesis and thus lifestyle factors such as age, smoking, obesity, unhealthy diet, premature menopause and exposure to ionizing radiation or cancer therapeutics. These factors through pathways mediated by CHIP and otherwise may lead to increased adverse cardiovascular events including accelerated atherosclerosis, heart failure and poor outcomes in aortic valve stenosis. Created with BioRender.com.