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. 2021 Oct 24;19:339. doi: 10.1186/s12951-021-01085-y

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — In vitro therapeutic efficacy of CLip-PC@CO-LC NPs. Dosage-dependent response of cell viability in A549 cells after treatment with DTX, CLip-PC@LC-DTX NPs, CLip-PC@LC-siPGAM1 NPs, CLip-PC@CO-LC NPs, or CLip-PC@CO-LC NPs (MMP-9) for a 24 h and b 48 h; data are represented as mean ± standard deviation (SD; n = 5). c Fluorescence-activated cell sorter analysis of apoptosis after annexin V-fluoresceine isothiocyanate/propidium iodide (FITC/PI) staining. d Percentages of apoptotic and necrotic cells were determined using Annexin V-PI; mean ± SD (n = 3). e Histograms showing the percentage of A549 cells in different phases of the cell cycle after a 48 h treatment with different DTX formulations. f S, G2/M, G1 phase distributions of various groups (results are shown as mean ± SD, n = 3)