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. Author manuscript; available in PMC: 2021 Oct 25.
Published in final edited form as: Annu Rev Virol. 2021 Jul 1;8(1):459–489. doi: 10.1146/annurev-virology-022221-063725

Figure 9.

Figure 9.

Processing of the flavivirus E protein during virion maturation. Immature virions are assembled at neutral pH in the ER. prM-E heterodimers organize as trimers on the surface of immature virions. As the immature virions traffic in the TGN, prM is cleaved by furin-like proteases into pr and M (not visible), and the E proteins reorganize as dimers. The pr peptide remains associated with the fusion peptide of E until the virion reaches the neutral pH of the extracellular space. Abbreviations: ER, endoplasmic reticulum; prM, pre-membrane; TGN, trans-Golgi network. Figure adapted from images created with BioRender.com.