Table 1.
The number of samples of each cancer and the corresponding number of germline variants and somatic mutations
| Cancer | Cancer # | Blood # | Adjacent normal # | Germline moderate | Germline high | Somatic moderate | Somatic high |
|---|---|---|---|---|---|---|---|
| Breast cancer | 959 | 936 | 23 | 10,911 (71) | 641 (5) | 65 (10) | 16 (3) |
| Colorectal cancer | 420 | 395 | 25 | 10,331 (241) | 621 (15) | 293 (79) | 81 (18) |
| Brain cancer | 763 | 763 | 0 | 9572 (55) | 550 (3) | 94 (30) | 23 (6) |
| Uterus cancer | 530 | 507 | 23 | 10,894 (103) | 650 (7) | 645 (152) | 160 (28) |
| Lung cancer | 730 | 713 | 17 | 9717 (37) | 555 (2) | 217 (15) | 43 (3) |
| Kidney cancer | 332 | 332 | 0 | 10,882 (124) | 634 (8) | 51 (6) | 14 (1) |
| Prostate cancer | 440 | 440 | 0 | 9744 (53) | 558 (4) | 34 (22) | 7 (3) |
Variants annotated with moderate effects are defined as missense mutations and in-frame shifts; variants annotated as high effects are defined as nonsense mutations
*Number in parenthesis is standard deviation (SD)