Table 5.
Effect size of GGT on NAFLD in prespecified and exploratory subgroups
| Characteristic | No of participants | HR (95%CI) | P value | P for interacion |
|---|---|---|---|---|
| Age, years | 0.5082 | |||
| < 30 | 2251 | 1.005 (0.999, 1.010) | 0.1221 | |
| 30 to < 40 | 3549 | 1.010 (1.006, 1.014) | < 0.001 | |
| 40 to < 50 | 2700 | 1.011 (1.006, 1.016) | < 0.001 | |
| 50 to < 60 | 1570 | 1.009 (1.003, 1.015) | 0.003 | |
| 60 to < 70 | 826 | 1.005 (0.996, 1.014) | 0.272 | |
| ≥ 70 | 1010 | 1.010 (1.003, 1.018) | 0.009 | |
| Gender | 0.2162 | |||
| Female | 5395 | 1.008 (1.005–1.011) | < 0.001 | |
| Male | 6511 | 1.011 (1.008–1.013) | < 0.001 | |
| BMI (kg/m2) | 0.1886 | |||
| < 18.5 | 942 | 1.038 (0.932, 1.155) | 0.499 | |
| ≥ 18.5, < 24 | 9377 | 1.013 (1.010, 1.015) | < 0.001 | |
| ≥ 24 | 1587 | 1.009 (1.005, 1.012) | < 0.001 | |
| SBP (mmHg) | 0.9399 | |||
| < 140 | 10,188 | 1.009 (1.007–1.012) | < 0.001 | |
| ≥ 140 | 1718 | 1.010 (1.005–1.014) | < 0.001 | |
| DBP (mmHg) | 0.7567 | |||
| < 90 | 10,941 | 1.010 (1.007–1.012) | < 0.001 | |
| ≥ 90 | 965 | 1.010 (1.005–1.016) | < 0.001 | |
| HDL-c (mmol/L) | 0.6828 | |||
| <1 | 1014 | 1.007 (1.001, 1.013) | 0.0179 | |
| ≥ 1 | 10,892 | 1.009 (1.006, 1.011) | < 0.001 | |
| ALT (U/L) | 0.0011 | |||
| ≤ 40 | 11,314 | 1.012 (1.010, 1.015) | < 0.001 | |
| >40 | 592 | 1.003 (0.998, 1.008) | 0.1828 | |
| Cr (mmol/L) | 0.0769 | |||
| < 82 | 5919 | 1.007 (1.003, 1.010) | < 0.001 | |
| ≥ 82 | 5987 | 1.011 (1.008, 1.014) | < 0.001 | |
| UA (umol//L) | 0.3937 | |||
| <420 | 10,962 | 1.010 (1.008, 1.012) | < 0.001 | |
| ≥ 420 | 944 | 1.007 (1.002, 1.013) | 0.007 | |
| FBG (mmol/L) | 0.2557 | |||
| <6.1 | 11,074 | 1.010 (1.008, 1.013) | < 0.001 | |
| ≥ 6.1 | 832 | 1.007 (1.002, 1.012) | 0.009 | |
Note 1: Above model adjusted for age, gender, BMI, SBP, DBP,, TC, TG, HDL-C, LDL-C, ALT, AST, ALP, ALB, GLB, TB, DBIL, BUN, Cr, UA, FBG.
Note 2: In each case, the model is not adjusted for the stratification variable