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. 2021 Oct 25;40:337. doi: 10.1186/s13046-021-02129-9

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Expression of TMEM44-AS1 in various tissues and cells. (A) Relative TMEM44-AS1 expression in glioma and normal brain tissues from our cohort. (***P < 0.001). (B) The TMEM44-AS1 expression is shown according to the histopathologic grades. (*P < 0.05, ***P < 0.001). (C) Relative TMEM44-AS1 expression in glioma and normal brain tissues from GTEX(n = 1136) and the TCGA database(n = 689). (***P < 0.001). (D) The TMEM44-AS1 expression is shown according to the histopathologic grades of TCGA gliomas. LGG (n = 523); GBM (n = 166). (***P < 0.001). (E) Kaplan-Meier curves of overall survival time of patients based on TMEM44-AS1 expression in glioma samples obtained from the TCGA database. (F) TMEM44-AS1 copy number segments in LGG and GBM were tested using the TCGA database. (***P < 0.001). (G) The correlation between TMEM44-AS1 copy number and TMEM44-AS1 expression in glioma from the TCGA database (n = 528). (H) Relative TMEM44-AS1 in NHA, U87, U251, LN-18, H4, SF126, T98G, A172 cell lines (*P < 0.05, **P < 0.01)