Fig. 2.

The overview of the proposed bidirectional adversarial domain adaptation method for nucleus detection. $G_{\mathcal{S}\mathcal{T}}/G_{\mathcal{T}\mathcal{S}}$ is the source-to-target/target-to-source generator and $D_{\mathcal{T}}/D_{\mathcal{S}}$ is its associated discriminator. $R_{\mathcal{S}}/R_{\mathcal{T}}$ is the source-/target-domain nucleus detector. Note that the target-domain detector $R_{\mathcal{T}}$ is learned with both gold-standard annotated, adapted source images and pseudo-labeled, real target images. The dashed gray arrow represents the transition from the training to testing stage. Here source and target data are H&E stained and IHC stained TMA microscopy images, respectively.