TABLE II.

The p-values of two-sample t-tests (a significance level of 0.05) comparing $\mathcal{S}+{\mathcal{T}}_{\mathcal{S}\leftrightarrow \mathcal{T}}^{UDA}$ to other methods, in terms of F₁ score. $\mathcal{S}$ and $\mathcal{T}$ denote the source and target domains, respectively. The first, second, third and forth panels represent our method’s variants, proposed UDA methods, proposed SSDA methods with 5% gold-standard annotations available in each target dataset, and the target-only models respectively, for different radii (i.e., r = 16 and 8) used to define gold-standard regions.

Method		r = 16						r = 8
		H&E ($\mathcal{T}$)		DAPI ($\mathcal{T}$)		IHC ($\mathcal{T}$)		H&E ($\mathcal{T}$)		DAPI ($\mathcal{T}$)		IHC ($\mathcal{T}$)
		DAPI ($\mathcal{S}$)	IHC ($\mathcal{S}$)	H&E ($\mathcal{S}$)	IHC ($\mathcal{S}$)	H&E ($\mathcal{S}$)	DAPI ($\mathcal{S}$)	DAPI ($\mathcal{S}$)	IHC ($\mathcal{S}$)	H&E ($\mathcal{S}$)	IHC ($\mathcal{S}$)	H&E ($\mathcal{S}$)	DAPI ($\mathcal{S}$)
1	Baseline	2×10−6	0.081	0.095	0.198	1.9×10−3	1.2×10−5	10−6	0.014	0.357	0.012	0.015	1.3×10−5
	$\mathcal{S}$	0.018	5.9×10−3	0.0	10−6	0.0	8.8×10−3	1.3×10−3	10−6	0.0	3×10−6	0.0	1.1×10−3
	${\mathcal{T}}_{\mathcal{S}\leftarrow \mathcal{T}}$	1.8×10−3	10−6	0.114	0.442	5×10−6	1.5×10−3	4.3×10−5	3×10−6	1.8×10−3	0.05	2×10−6	1.9×10−4
	${\mathcal{T}}_{\mathcal{S}\leftarrow \mathcal{T}}$	1.5×10−3	0.0	5×10−6	0.442	0.0	2.3×10−3	9.2×10−3	0.0	0.0	4×10−6	0.0	0.011
2	${\mathcal{T}}_{\mathcal{S}\leftrightarrow \mathcal{T}}^{UDA}$	0.546	3.1×10−3	0.077	0.703	0.598	0.572	0.248	0.035	0.018	0.327	0.856	0.319
	$\mathcal{S}+{\mathcal{T}}_{\mathcal{S}\leftrightarrow \mathcal{T}}^{UDA}$	-	-	-	-	-	-	-	-	-	-	-	-
3	${\mathcal{T}}_{\mathcal{S}\leftrightarrow \mathcal{T}}^{SSDA}$	4.3×10−5	7.7×10−4	1.1×10−5	1.4×10−3	0.071	1.7×10−5	5.7×10−5	0.594	4×10−6	5.6×10−3	0.150	4.6×10−5
	$\mathcal{S}+{\mathcal{T}}_{\mathcal{S}\leftrightarrow \mathcal{T}}^{SSDA}$	6×10−6	10−6	9×10−6	0.222	0.042	3×10−6	5×10−6	1.5×10−4	6×10−6	0.068	0.072	4×10−6
4	5%-target	2.4×10−3	0.847	1.5×10−5	0.012	0.576	2.1×10−5	2.1×10−3	0.059	5×10−6	0.036	0.672	4×10−6
	Full-target	0.0	0.0	0.0	1.2×10−4	2×10−6	0.0	0.0	0.0	0.0	3.3×10−5	10−6	0.0