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. 2021 Oct 24;21:557. doi: 10.1186/s12935-021-02271-6

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Elevated expression of MKRN3 in SCCHN. a, b Differential expression of MKRN3 in SCCHN tissue samples according to TCGA data (a) and paired difference analyses (b). c MKRN3 mRNA expression levels in patients with normal tumor tissues. d Relative expression level of MKRN3 mRNA in six different SCCHN cell lines and an immortalized non-malignant cell line derived from oral mucosa (DOK). The gene expression was normalized to GAPDH. e, f Representative immunohistochemical staining shows the expression of the MKRN3 protein in normal (e) and SCCHN tissues (f) according to TCGA (200× , 400×). Data are presented as the mean ± standard deviation. P-values were calculated using the Student’s t-test. *P < 0.05; **P < 0.01; ***P < 0.001. TCGA, The Cancer Genome Atlas