Table 4.

Cox model analysis of disease-free survival

Parameters	Relative risk (95% CI)	P-value
Univariate
Age	1.246(0.919–1.691)	0.157
Gender	0.818(0.519–1.137)	0.232
Smoking	0.867(0.643–1.168)	0.348
Alcohol	0.970(0.703–1.337)	0.851
Histological grade	1.036(0.772–1.390)	0.815
Stage	0.541(0.354–0.827)	0.005
T classification	2.038(1.439–2.888)	0.000
Lymph node metastasis	1.759(1.298–2.483)	0.000
Distant metastasis	1.136(1.019–1.266)	0.022
MKRN3 expression	1.003(1.001–1.005)	0.013
Multivariate
Lymph node metastasis	1.699(1.215–2.375)	0.002
T classification	1.900(1.328–2.718)	0.000
Distant metastasis	1.135(1.015–1.269)	0.027
MKRN3 expression	1.003(1.001–1.005)	0.006

The bolditalic values represent P < 0.05

All the clinicopathological variables listed in the table were included in the univariate and multivariate analyses

95% CI, 95% confidence interval