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. 2021 Oct 25;10:48. doi: 10.1186/s40164-021-00243-0

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — 19-HB inhibited NSCLC growth in vivo. Xenograft Balb/c nude mice model was established with NCI-H1299 cells, and the mice were euthanized after completing the treatment. a Tumor volumes of tumor-bearing Bulb/c mice measured on the indicated days. b Tumor size and tumor weights measured. c Serum biochemical indexes to reflect the hepatorenal toxicity of 19-HB. d IHC staining for Ki67 and immunofluorescence staining for TUNEL assay performed in tumor mass, and the positive rate of Ki67 and TUNEL determined on IHC staining afterward (*P < 0.05 vs. control, **P < 0.01 vs. control)