Table 3.
Relationships of PDX1 and MC4R polymorphisms with T2DM risk stratified by age and sex
| Gene SIP | Model | Genotype | > 60 | ≤ 60 | Male | Female | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | |||
|
PDX1 rs9581943 |
Allele | G | 1.00 | 1.00 | 1.00 | 1.00 | ||||
| A | 0.99 (0.76–1.28) | 0.919 | 0.84 (0.65–1.09) | 0.180 | 0.94 (0.75–1.16) | 0.544 | 0.87 (0.62–1.22) | 0.424 | ||
| Codominant | GG | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| AA | 1.05 (0.60–1.84) | 0.852 | 0.79 (0.45–1.38) | 0.409 | 1.05 (0.67–1.66) | 0.829 | 0.77 (0.37–1.60) | 0.481 | ||
| AG | 0.86 (0.58–1.27) | 0.439 | 0.66 (0.45–0.98) | 0.039 | 0.73 (0.5–1.00) | 0.049 | 0.85 (0.51–1.40) | 0.516 | ||
| Dominant | GG | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| AA-AG | 0.90 (0.63–1.30) | 0.580 | 0.69 (0.48–1.00) | 0.049 | 0.80 (0.59–1.07) | 0.130 | 0.83 (0.51–1.34) | 0.439 | ||
| Recessive | AG-GG | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| AA | 1.14 (0.67–1.92) | 0.634 | 0.99 (0.59–1.67) | 0.982 | 1.24 (0.81–1.89) | 0.330 | 0.84 (0.43–1.66) | 0.620 | ||
| Additive | – | 0.98 (0.76–1.27) | 0.873 | 0.83 (0.63–1.08) | 0.156 | 0.94 (0.76–1.16) | 0.554 | 0.87 (0.62–1.22) | 0.421 | |
|
PDX1 rs7981781 |
Allele | G | 1.00 | 1.00 | 1.00 | 1.00 | ||||
| A | 0.96 (0.75–1.23) | 0.753 | 1.08 (0.84–1.40) | 0.542 | 0.94 (0.76–1.16) | 0.558 | 1.22 (0.88–1.70) | 0.241 | ||
| Codominant | GG | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| AA | 1.00 (0.60–1.67) | 0.999 | 1.23 (0.72–2.08) | 0.449 | 0.96 (0.64–1.46) | 0.856 | 1.46 (0.72–2.96) | 0.300 | ||
| AG | 0.89 (0.59–1.35) | 0.584 | 0.91 (0.61–1.35) | 0.628 | 0.70 (0.50–0.97) | 0.033 | 1.41 (0.83–2.39) | 0.203 | ||
| Dominant | GG | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| AA-AG | 0.92 (0.62–1.36) | 0.683 | 0.98 (0.67–1.43) | 0.925 | 0.77 (0.56–1.05) | 0.096 | 1.42 (0.86–2.35) | 0.172 | ||
| Recessive | AG-GG | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| AA | 1.07 (0.69–1.68) | 0.757 | 1.30 (0.81–2.09) | 0.281 | 1.19 (0.83–1.72) | 0.352 | 1.18 (0.63–2.20) | 0.615 | ||
| Additive | – | 0.99 (0.77–1.27) | 0.928 | 1.07 (0.83–1.38) | 0.603 | 0.94 (0.77–1.16) | 0.567 | 1.24 (0.88–1.75) | 0.225 | |
|
MC4R rs6567160 |
Allele | T | 1.00 | 1.00 | 1.00 | 1.00 | ||||
| C | 1.32 (0.99–1.75) | 0.060 | 0.77 (0.57–1.04) | 0.091 | 0.96 (0.7–1.23) | 0.756 | 1.16 (0.79–1.71) | 0.460 | ||
| Codominant | TT | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| CC | 1.81 (0.91–3.58) | 0.091 | 0.33 (0.13–0.81) | 0.015 | 0.70 (0.37–1.32) | 0.271 | 1.41 (0.57–3.54) | 0.459 | ||
| CT | 1.22 (0.82–1.80) | 0.322 | 0.96 (0.65–1.40) | 0.815 | 1.11 (0.81–1.52) | 0.522 | 1.08 (0.65–1.81) | 0.758 | ||
| Dominant | TT | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| CC-CT | 1.31 (0.91–1.89) | 0.144 | 0.84 (0.58–1.21) | 0.340 | 1.04 (0.77–1.39) | 0.820 | 1.14 (0.70–1.84) | 0.596 | ||
| Recessive | CT-TT | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| CC | 1.68 (0.86–3.28) | 0.129 | 0.33 (0.14–0.81) | 0.016 | 0.68 (0.36–1.26) | 0.215 | 1.37 (0.56–3.37) | 0.489 | ||
| Additive | – | 1.29 (0.97–1.71) | 0.077 | 0.77 (0.57–1.04) | 0.085 | 0.96 (0.76–1.23) | 0.760 | 1.14 (0.79–1.66) | 0.484 | |
|
MC4R rs663129 |
Allele | G | 1.00 | 1.00 | 1.00 | 1.00 | ||||
| A | 1.32 (0.99–1.75) | 0.060 | 0.79 (0.59–1.07) | 0.125 | 0.98 (0.77–1.25) | 0.852 | 1.16 (0.79–1.71) | 0.460 | ||
| Codominant | GG | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| AA | 1.81 (0.91–3.58) | 0.091 | 0.33 (0.13–0.82) | 0.017 | 0.71 (0.38–1.33) | 0.284 | 1.41 (0.57–3.54) | 0.459 | ||
| AG | 1.22 (0.82–1.80) | 0.322 | 0.99 (0.68–1.45) | 0.966 | 1.14 (0.83–1.55) | 0.424 | 1.08 (0.65–1.81) | 0.758 | ||
| Dominant | GG | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| AA-AG | 1.31 (0.91–1.89) | 0.144 | 0.87 (0.60–1.25) | 0.441 | 1.06 (0.79–1.43) | 0.704 | 1.14 (0.70–1.84) | 0.596 | ||
| Recessive | AG-GG | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| AA | 1.68 (0.86–3.28) | 0.129 | 0.33 (0.14–0.81) | 0.016 | 0.68 (0.36–1.26) | 0.215 | 1.37 (0.56–3.37) | 0.489 | ||
| Additive | – | 1.29 (0.97–1.71) | 0.077 | 0.78 (0.58–1.06) | 0.116 | 0.98 (0.77–1.24) | 0.854 | 1.14 (0.79–1.66) | 0.484 | |
|
MC4R rs17782313 |
Allele | T | 1.00 | 1.00 | 1.00 | 1.00 | ||||
| C | 1.32 (0.99–1.75) | 0.060 | 0.81 (0.60–1.09) | 0.167 | 0.98 (0.77–1.26) | 0.901 | 1.18 (0.80–1.74) | 0.403 | ||
| Codominant | TT | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| CC | 1.81 (0.91–3.58) | 0.091 | 0.34 (0.14–0.83) | 0.018 | 0.71 (0.38–1.34) | 0.291 | 1.43 (0.57–3.58) | 0.443 | ||
| CT | 1.22 (0.82–1.80) | 0.322 | 1.03 (0.71–1.51) | 0.867 | 1.15 (0.84–1.58) | 0.378 | 1.12 (0.67–1.87) | 0.660 | ||
| Dominant | TT | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| CC-CT | 1.31 (0.91–1.89) | 0.144 | 0.90 (0.62–1.30) | 0.569 | 1.07 (0.80–1.44) | 0.648 | 1.17 (0.73–1.90) | 0.515 | ||
| Recessive | CT-TT | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| CC | 1.68 (0.86–3.28) | 0.129 | 0.33 (0.14–0.81) | 0.016 | 0.68 (0.36–1.26) | 0.215 | 1.37 (0.56–3.37) | 0.489 | ||
| Additive | – | 1.29 (0.97–1.71) | 0.077 | 0.80 (0.59–1.09) | 0.159 | 0.99 (0.77–1.25) | 0.903 | 1.16 (0.80–1.69) | 0.426 | |
|
MC4R rs12969709 |
Allele | C | 1.00 | 1.00 | 1.00 | 1.00 | ||||
| A | 1.13 (0.85–1.51) | 0.406 | 0.78 (0.57–1.06) | 0.111 | 0.91 (0.71–1.16) | 0.449 | 1.03 (0.69–1.53) | 0.884 | ||
| Codominant | CC | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| AA | 1.37 (0.67–2.80) | 0.396 | 0.27 (0.10–0.75) | 0.012 | 0.58 (0.29–1.15) | 0.117 | 1.02 (0.39–2.70) | 0.965 | ||
| AC | 1.12 (0.76–1.65) | 0.583 | 0.98 (0.67–1.43) | 0.900 | 1.06 (0.77–1.45) | 0.726 | 1.05 (0.63–1.75) | 0.867 | ||
| Dominant | CC | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| AA-AC | 1.16 (0.80–1.67) | 0.442 | 0.85 (0.59–1.23) | 0.397 | 0.98 (0.72–1.32) | 0.879 | 1.04 (0.64–1.69) | 0.871 | ||
| Recessive | AC-CC | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| AA | 1.31 (0.65–2.66) | 0.449 | 0.27 (0.10–0.75) | 0.012 | 0.57 (0.29–1.11) | 0.099 | 1.01 (0.39–2.62) | 0.989 | ||
| Additive | – | 1.14 (0.86–1.53) | 0.361 | 0.77 (0.56–1.05) | 0.098 | 0.91 (0.71–1.16) | 0.451 | 1.03 (0.70–1.51) | 0.893 | |
|
MC4R rs11663816 |
Allele | T | 1.00 | 1.00 | 1.00 | 1.00 | ||||
| C | 1.21 (0.90–1.61) | 0.203 | 0.75 (0.55–1.02) | 0.067 | 0.92 (0.72–1.17) | 0.488 | 1.07 (0.72–1.60) | 0.727 | ||
| Codominant | TT | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| CC | 1.78 (0.85–3.73) | 0.127 | 0.31 (0.11–0.88) | 0.027 | 0.70 (0.35–1.39) | 0.304 | 1.44 (0.53–3.96) | 0.476 | ||
| CT | 1.07 (0.73–1.58) | 0.726 | 0.88 (0.60–1.28) | 0.504 | 0.98 (0.72–1.34) | 0.923 | 0.94 (0.57–1.57) | 0.823 | ||
| Dominant | TT | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| CC-CT | 1.17 (0.81–1.68) | 0.412 | 0.80 (0.55–1.15) | 0.223 | 0.94 (0.70–1.27) | 0.703 | 1.01 (0.62–1.64) | 0.968 | ||
| Recessive | CT-TT | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| CC | 1.74 (0.84–3.59) | 0.137 | 0.32 (0.11–0.91) | 0.032 | 0.70 (0.35–1.38) | 0.305 | 1.47 (0.54–3.98) | 0.447 | ||
| Additive | – | 1.21 (0.90–1.61) | 0.210 | 0.75 (0.55–1.03) | 0.072 | 0.92 (0.71–1.17) | 0.486 | 1.07 (0.73–1.57) | 0.739 | |
SNP single nucleotide polymorphism, OR odds ratio, 95% CI 95% confidence interval
p values were calculated by logistic regression analysis with adjustment for age and gender
Bold values indicate statistical significance (p < 0.05)