Table 4.
The associations between PDX1 and MC4R polymorphisms and the risk of T2DM stratified by smoking, drinking status
| Gene SIP | Model | Genotype | Smoking | Non-smoking | Drinking | Non-drinking | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | |||
|
PDX1 rs11619319 |
Allele | A | 1.00 | 1.00 | 1.00 | 1.00 | ||||
| G | 0.82 (0.58–1.15) | 0.246 | 0.92 (0.70–1.21) | 0.535 | 0.80 (0.55–1.18) | 0.263 | 0.93 (0.71–1.22) | 0.608 | ||
| Codominant | AA | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| GG | 0.75 (0.37–1.50) | 0.410 | 0.84 (0.48–1.49) | 0.558 | 0.67 (0.30–1.47) | 0.313 | 0.89 (0.50–1.56) | 0.676 | ||
| GA | 0.61 (0.34–1.09) | 0.098 | 0.77 (0.48–1.23) | 0.274 | 0.51 (0.27–0.97) | 0.039 | 0.81 (0.51–1.29) | 0.381 | ||
| Dominant | AA | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| GG-GA | 0.65 (0.38–1.13) | 0.125 | 0.79 (0.51–1.23) | 0.299 | 0.55 (0.30–1.01) | 0.054 | 0.83 (0.54–1.29) | 0.418 | ||
| Recessive | GA-AA | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| GG | 1.02 (0.57–1.83) | 0.943 | 1.00 (0.62–1.62) | 0.998 | 1.01 (0.63–1.63) | 0.957 | 1.01 (0.63–1.63) | 0.957 | ||
| Additive | – | 0.85 (0.61–1.19) | 0.346 | 0.91 (0.69–1.20) | 0.501 | 0.93 (0.71–1.23) | 0.623 | 0.93 (0.71–1.23) | 0.623 | |
|
PDX1 rs2293941 |
Allele | G | 1.00 | 1.00 | 1.00 | 1.00 | ||||
| A | 0.83 (0.59–1.16) | 0.274 | 0.91 (0.69–1.20) | 0.515 | 0.80 (0.55–1.18) | 0.264 | 0.94 (0.71–1.23) | 0.647 | ||
| Codominant | GG | 1.00 | 1.00 | 1.00 | ||||||
| AA | 0.77 (0.38–1.54) | 0.454 | 0.85 (0.48–1.50) | 0.568 | 0.68 (0.31–1.48) | 0.326 | 0.90 (0.51–1.57) | 0.703 | ||
| AG | 0.64 (0.36–1.13) | 0.124 | 0.80 (0.50–1.26) | 0.331 | 0.51 (0.27–0.97) | 0.040 | 0.85 (0.54–1.34) | 0.477 | ||
| Dominant | GG | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| AA-AG | 0.67 (0.39–1.16) | 0.156 | 0.81 (0.52–1.25) | 0.345 | 0.56 (0.30–1.02) | 0.056 | 0.86 (0.56–1.33) | 0.499 | ||
| Recessive | AG-GG | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| AA | 1.02 (0.57–1.83) | 0.943 | 0.98 (0.61–1.59) | 0.939 | 1.03 (0.53–2.00) | 0.935 | 1.00 (0.62–1.61) | 0.986 | ||
| Additive | – | 0.86 (0.62–1.21) | 0.384 | 0.91 (0.69–1.20) | 0.511 | 0.79 (0.54–1.16) | 0.231 | 0.94 (0.71–1.24) | 0.654 | |
|
PDX1 rs7981781 |
Allele | G | 1.00 | 1.00 | 1.00 | 1.00 | ||||
| A | 0.76 (0.54–1.07) | 0.117 | 0.95 (0.72–1.25) | 0.726 | 0.73 (0.50–1.08) | 0.111 | 0.96 (0.73–1.27) | 0.786 | ||
| Codominant | GG | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| AA | 0.68 (0.34–1.36) | 0.277 | 0.92 (0.53–1.61) | 0.775 | 0.57 (0.26–1.26) | 0.167 | 0.94 (0.54–1.64) | 0.834 | ||
| AG | 0.50 (0.29–0.89) | 0.018 | 0.89 (0.57–1.41) | 0.628 | 0.47 (0.25–0.88) | 0.019 | 0.92 (0.59–1.44) | 0.716 | ||
| Dominant | GG | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| AA-AG | 0.55 (0.32–0.95) | 0.030 | 0.90 (0.59–1.38) | 0.636 | 0.49 (0.27–0.90) | 0.022 | 0.93 (0.61–1.41) | 0.724 | ||
| Recessive | AG-GG | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| AA | 1.03 (0.57–1.86) | 0.919 | 0.99 (0.61–1.60) | 0.962 | 0.92 (0.47–1.81) | 0.811 | 0.99 (0.61–1.60) | 0.972 | ||
| Additive | – | 0.80 (0.57–1.11) | 0.175 | 0.95 (0.72–1.26) | 0.737 | 0.72 (0.49–1.07) | 0.100 | 0.97 (0.74–1.27) | 0.803 | |
|
MC4R rs6567160 |
Allele | T | 1.00 | 1.00 | 1.00 | 1.00 | ||||
| C | 0.92 (0.61–1.37) | 0.665 | 1.36 (0.98–1.90) | 0.068 | 0.90 (0.56–1.46) | 0.682 | 1.14 (0.83–1.58) | 0.416 | ||
| Codominant | TT | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| CC | 0.99 (0.33–2.93) | 0.980 | 1.37 (0.58–3.20) | 0.472 | 1.13 (0.29–4.41) | 0.857 | 0.99 (0.45–2.18) | 0.988 | ||
| CT | 0.86 (0.52–1.44) | 0.569 | 1.60 (1.04–2.45) | 0.032 | 0.80 (0.44–1.45) | 0.460 | 1.34 (0.87–2.04) | 0.180 | ||
| Dominant | TT | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| CC-CT | 0.88 (0.54–1.43) | 0.601 | 1.56 (1.04–2.34) | 0.031 | 0.83 (0.47–1.47) | 0.532 | 1.27 (0.85–1.90) | 0.237 | ||
| Recessive | CT-TT | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| CC | 1.04 (0.36–3.04) | 0.942 | 1.16 (0.50–2.69) | 0.725 | 1.22 (0.32–4.67) | 0.776 | 0.89 (0.41–1.92) | 0.772 | ||
| Additive | – | 0.92 (0.62–1.37) | 0.688 | 1.37 (0.99–1.92) | 0.061 | 0.90 (0.56–1.45) | 0.673 | 1.15 (0.83–1.58) | 0.407 | |
|
MC4R rs663129 |
Allele | G | 1.00 | 1.00 | 1.00 | 1.00 | ||||
| A | 0.93 (0.62–1.38) | 0.713 | 1.39 (0.99–1.94) | 0.053 | 0.96 (0.59–1.55) | 0.869 | 1.14 (0.83–1.58) | 0.416 | ||
| Codominant | GG | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| AA | 0.99 (0.33–2.95) | 0.990 | 1.38 (0.59–3.23) | 0.459 | 1.17 (0.30–4.54) | 0.825 | 0.99 (0.45–2.18) | 0.988 | ||
| AG | 0.88 (0.53–1.47) | 0.624 | 1.64 (1.07–2.52) | 0.023 | 0.88 (0.48–1.58) | 0.660 | 1.34 (0.87–2.04) | 0.180 | ||
| Dominant | GG | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| AA-AG | 0.89 (0.55–1.46) | 0.655 | 1.60 (1.07–2.40) | 0.023 | 0.91 (0.51–1.60) | 0.735 | 1.27 (0.85–1.90) | 0.237 | ||
| Recessive | AG-GG | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| AA | 1.04 (0.36–3.04) | 0.942 | 1.16 (0.50–2.69) | 0.725 | 1.22 (0.32–4.67) | 0.776 | 0.89 (0.41–1.92) | 0.772 | ||
| Additive | – | 0.93 (0.63–1.39) | 0.734 | 1.40 (1.00–1.95) | 0.049 | 0.96 (0.60–1.54) | 0.855 | 1.15 (0.83–1.58) | 0.407 | |
|
MC4R rs17782313 |
Allele | T | 1.00 | 1.00 | 1.00 | 1.00 | ||||
| C | 0.93 (0.62–1.38) | 0.713 | 1.43 (1.02–2.00) | 0.036 | 0.96 (0.59–1.55) | 0.869 | 1.18 (0.85–1.63) | 0.329 | ||
| Codominant | TT | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| CC | 0.99 (0.33–2.95) | 0.990 | 1.40 (0.60–3.28) | 0.439 | 1.17 (0.30–4.54) | 0.825 | 1.01 (0.46–2.21) | 0.977 | ||
| CT | 0.88 (0.53–1.47) | 0.624 | 1.72 (1.12–2.64) | 0.014 | 0.88 (0.48–1.58) | 0.660 | 1.40 (0.92–2.15) | 0.118 | ||
| Dominant | TT | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| CC-CT | 0.89 (0.55–1.46) | 0.655 | 1.66 (1.11–2.50) | 0.014 | 0.91 (0.51–1.60) | 0.735 | 1.33 (0.89–1.99) | 0.163 | ||
| Recessive | CT-TT | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| CC | 1.04 (0.36–3.04) | 0.942 | 1.16 (0.50–2.69) | 0.725 | 1.22 (0.32–4.67) | 0.776 | 0.89 (0.41–1.92) | 0.772 | ||
| Additive | – | 0.93 (0.63–1.39) | 0.734 | 1.44 (1.03–2.01) | 0.034 | 0.96 (0.60–1.54) | 0.855 | 1.18 (0.85–1.63) | 0.317 | |
SNP single nucleotide polymorphism, OR odds ratio, 95% CI 95% confidence interval
p values were calculated by logistic regression analysis with adjustment for age and gender
Bold values indicate statistical significance (p < 0.05)