Table 6.
Haplotype analysis of PDX1 and MC4R SNPs with T2DM risk
| Gene | SNP | Haplotype | Frequency in cases | Frequency in controls | With adjustment | Without adjustment | ||
|---|---|---|---|---|---|---|---|---|
| OR (95%CI) | p | OR (95%CI) | p | |||||
| PDX1 | rs11619319|rs2293941 | GA | 0.446 | 0.440 | 1.02 (0.86–1.22) | 0.791 | 1.02 (0.86–1.22) | 0.792 |
| PDX1 | rs11619319|rs2293941 | AG | 0.451 | 0.444 | 1.03 (0.86–1.23) | 0.755 | 1.03 (0.86–1.23) | 0.756 |
| PDX1 | rs9581943|rs7981781 | GA | 0.432 | 0.431 | 1.00 (0.84–1.20) | 0.969 | 1.00 (0.84–1.20) | 0.970 |
| PDX1 | rs9581943|rs7981781 | AG | 0.350 | 0.372 | 0.91 (0.72–1.09) | 0.307 | 0.91 (0.76–1.09) | 0.308 |
| PDX1 | rs9581943|rs7981781 | GG | 0.216 | 0.197 | 1.13 (0.91–1.40) | 0.283 | 1.13 (0.91–1.40) | 0.284 |
| MC4R | rs6567160|rs663129|rs17782313 | CAC | 0.237 | 0.233 | 1.02 (0.84–1.25) | 0.819 | 1.02 (0.84–1.25) | 0.820 |
| MC4R | rs6567160|rs663129|rs17782313 | TGT | 0.239 | 0.235 | 1.02 (0.84–1.25) | 0.818 | 1.02 (0.84–1.25) | 0.819 |
| MC4R | rs11663816|rs12970134 | CA | 0.204 | 0.217 | 0.93 (0.75–1.15) | 0.510 | 0.93 (0.75–1.15) | 0.509 |
| MC4R | rs11663816|rs12970134 | CG | 0.015 | 0.011 | 1.38 (0.63–3.04) | 0.423 | 1.38 (0.63–3.04) | 0.423 |
| MC4R | rs11663816|rs12970134 | TG | 0.221 | 0.228 | 0.97 (0.78–1.19) | 0.746 | 0.97 (0.78–1.19) | 0.744 |
SNP single nucleotide polymorphism, OR odd ratios, CI confidence interval