Fig. 1.

Drug classes negatively connected to the GBM signature. A Pipeline for drug discovery using connectivity mapping. B Drug classes with negative connectivity scores (> − 80). HDAC inhibitors were found to be the most enriched class. C The negatively connected drugs from CMap compared with a four-way Venn diagram. The 12 drugs negatively connected to all datasets were then studied more closely. D Top 12 drugs exhibiting negative connection with GBM signature common across the four datasets