Table 2.

Agreed results of AMSTAR-2 for fibromyalgia

Author (date), CAM	1. Were PICO components listed?	2. Protocol reported? Any deviations justified?	3. Study design justified?	4. Comprehensive literature search?	5. Was study selection performed in duplicate?	6. Was data extraction performed in duplicate?	7. List of excluded studies? Were these justified?	8. Characteristics of studies provided in detail?
Fibromyalgia
Multiple cam therapies
Holdcraft 2003 [14]	No	No	No	No	No	No	No	No
Baronowsky 2009 [15]	No	No	Yes	No	No	No	No	No
Terhorst 2011, 2012 [16, 17]	Yes	No	No	No	Yes	No	No	No
De Silva 2010 [18]	No	No	No	No	Yes	Yes	No	No
Homoeopathy
Perry 2010 [19]	Yes	No	No	PY	Yes	Yes	No	PY
Boehm 2014 [20]	No	No	No	PY	Yes	Yes	No	Yes
Chiropractic treatment
Ernst 2009 [21]	Yes	No	No	No	No	Yes	No	No
Acupuncture
Mayhew and Ernst 2007 [22]	No	No	No	PY	No	Yes	No	PY
Daya 2007 [23]	No	No	No	PY	No	No	No	PY
Langhorst 2010 [24]	Yes	No	No	PY	Yes	Yes	No	Yes
Martin-Sanchez 2009 [25]	Yes	No	No	PY	No	No	No	No
Cao 2013 [26]	Yes	No	No	PY	yes	Yes	No	Yes
Deare 2013 [13]	Yes	Yes	No	Yes	Yes	Yes	Yes	Yes
Yang 2014 [27]	Yes	No	No	PY	Yes	Yes	No	No
Herbal medicines
de Souza Nascimento 2013 [28]	Yes	No	yes	No	No	Yes	No	PY
Colic
Multiple cam therapies
Perry 2011 [29]	Yes	PY	No	PY	PY	Yes	No	Yes
Bruyas-Bertholon 2012 [30]	No	No	No	No	No	No	No	PY
Harb 2016 [31]	Yes	No	No	No	Yes	Yes	No	PY
Gutierrez-Castrellon 2017 [32]	Yes	No	No	No	No	No	No	No
Manipulation therapies
Dobson 2012 [33]	Yes	Yes	No	Yes	Yes	Yes	Yes	Yes
Gleberzon 2012 [34]	No	No	No	PY	No	Yes	No	PY
Carnes 2017 [35]	No	PY	No	PY	Yes	Yes	No	PY
Acupuncture
Skejeie 2018 [36]	Yes	PY	No	Yes	Yes	Yes	No	Yes
Herbal medicines
Anheyer 2017 [37]	No	No	No	No	No	Yes	No	Yes
Probiotics
Sung 2013 [38]	Yes	No	No	No	Yes	Yes	Yes	PY
Anabrees 2013 [39]	Yes	PY	No	PY	No	Yes	No	Yes
Urbanska 2014 [40]	Yes	No	No	PY	No	No	No	PY
Xu 2015 [41]	No	No	No	PY	Yes	Yes	No	Yes
Schreck Bird 2017 [42]	Yes	No	No	No	Yes	No	No	Yes
Dryl 2018 [43]	Yes	No	No	No	No	No	No	PY
Sung 2018 [44]	Yes	PY	No	PYb	No	No	No	No

9. Risk of bias assessed?	10. Sources of funding of included studies?	11. Methods used to combine the findings of studies appropriate? Test on heterogeneity?	12. If meta-analysis performed was RoB accounted for?	13. Was RoB discussed in individual studies?	14. Was there discussion of any heterogeneity observed in the results?	15. If a quantitative synthesis, was publication bias investigated and discussed in relation to the results?	16. Reviewers’ conflict of interests stated?	Confidence in the review
Fibromyalgia
Multiple cam therapies
PY	No	No MA	No MA	Yes		No MA	No	CL
No	No	No MA	No MA	Yes	No	No MA	No	CL
Yes	No	No	No	No	No	No	Yes	CL
No	No	No MA	No MA	Yes	Yes	No MA	Yes	CL
Homoeopathy
Yes	No	No MA	No MA	Yes	Yes	No MA	Yes	CL
Yes	No	Yes	No	No	Yes	No	Yes	CL
Chiropractic treatment
No	No	No MA	No MA	Yes	No	No MA	Yes	CL
Acupuncture
No	NO	No MA	No MA	Yes	Yes	No MA	Yes	CL
PY	No	No MA	No MA	No	No	No MA	No	CL
Yes	No	Yes	Yes	Yes	Yes	No	No	CL
No	No	No	No	No	Yes	No	Yes	CL
Yes	No	Yes	No	Yes	Yes	Yes	Yes	CL
Yes	Yes	Yes	Yes	Yes	Yes	No	Yes	Low
Yes	No	No	No	No	Noa	Yes	No	CL
Herbal medicines
Yes	No	No MA	No MA	No	No	No MA	Yes	CL
Colic
Multiple cam therapies
Yes	No	No MA	No MA	Yes	No	No MA	Yes	Low
PY	No	No MA	No MA	No	No	No MA	No	CL
Yes	No	Yes	Yes	Yes	No	Yes	Yes	CL
No	No	No	No	Yes	No	Yes	No	CL
Manipulation therapies
Yes	No	Yes	Yes	Yes	Noa	Yes	Yes	High
No	No	No MA	No MA	Yes	No	No MA	No	CL
Yes	No	No	No	No	No	No	No	CL
Acupuncture
Yes	No	Yes	Yes	Yes	Yes	No	Nod	Low
Herbal medicines
Yes	No	No MA	No MA	No	No	No MA	Yes	CL
Probiotics
Yes	No	Yes	No	Yes	No	No	Yes	CL
Yes	No	Yes	No	Yes	Yes	No	Yes	Low
Yes	Yes	No	No	No	No	No	No	CL
Yes	No	Yes	No	No	No	No	Yes	CL
Yes	No	No	No	No	No	No	No	CL
Yes	No	No	No	No	No	No	No	CL
Yes	No	Yes	Yes	Yes	Yes	Yes	Noc	Low

CL critically low, PY partial yes, MA meta-analysis, PICO participants, intervention, comparator, outcomes, RoB risk of bias

^aToo few studies to perform a test of heterogeneity

^bNot fully searched and search conducted Dec 2014

^cConflict of interest occurred but no indication of how it was dealt with

^dAll included studies were by the author team but did not indicate how this was dealt with

Italicised columns represent the critical domains (see Appendix, Table 15)