Table 5.
Multivariate Competing Risk Analysis of Predictors of Wait-list Removal for Improvement
| Predictor variables | Sub HR (95 % CI) | P Value |
|---|---|---|
| ALD (vs non-ALD) | ||
| At 6 months after listing* | 1.06 (0.89–1.26) | 0.496 |
| At 1 year after listing* | 1.49 (1.30–1.69) | < 0.001 |
| At 2 years after listing* | 2.91 (2.35–3.61) | < 0.001 |
|
| ||
| Age (vs 18–34) | ||
| 35–49 | 0.70 (0.58–0.84) | < 0.001 |
| 50–64 | 0.57 (0.48–0.68) | < 0.001 |
| 65 and older | 0.84 (0.68–1.03) | 0.10 |
|
| ||
| Female Sex | 1.33 (1.19–1.47) | < 0.001 |
|
| ||
| BMI (vs 20–29) | ||
| Less than 20 | 1.30 (1.02–1.65) | 0.04 |
| 30–34 | 0.73 (0.63–0.84) | < 0.001 |
| 35–39 | 0.81 (0.67–0.98) | 0.03 |
| > or = 40 | 0.79 (0.59–1.06) | 0.11 |
|
| ||
| Blood group (vs AB) | ||
| A | 1.41 (1.03–1.94) | 0.03 |
| B | 1.45 (1.03–2.03) | 0.03 |
| O | 1.40 (1.02–1.92) | 0.04 |
|
| ||
| Ascites (vs Absent) | ||
| Slight | 0.43 (0.37–0.48) | < 0.001 |
| Moderate or more | 0.15 (0.12–0.20) | < 0.001 |
|
| ||
| Spontaneous bacterial peritonitis | 0.84 (0.64–1.11) | 0.23 |
|
| ||
| Encephalopathy (vs none) | ||
| Grade 1–2 | 0.42 (0.36–0.48) | < 0.001 |
| Grade 3–4 | 0.13 (0.07–0.22) | < 0.001 |
|
| ||
| Diabetes | 0.83 (0.72–0.95) | 0.007 |
|
| ||
| MELD at listing (vs < 15) | ||
| 15–24 | 0.62 (0.54–0.70) | < 0.001 |
| 25–34 | 0.74 (0.60–0.92) | 0.006 |
| ≥ 35 | 0.72 (0.53–0.99) | 0.04 |
|
| ||
| Region for listing, by grouping of wait-time (vs short) | ||
| Moderate | 0.84 (0.74–0.95) | 0.007 |
| Long | 0.64 (0.55–0.74) | < 0.001 |
|
| ||
| Cohort (vs 2002–2006) | ||
| 2007–2011 | 2.12 (1.82–2.47) | < 0.001 |
| 2012–2016 | 3.07 (2.64–3.57) | < 0.001 |
Significant interaction between alcoholic liver disease and time since listing was identified (p < 0.001). Therefore, subhazard ratios are reported at 6 months, 1 year, and 2 years after listing.