Table 5.
Best Models of Gene–Gene Interactions Among the Four COPD Associated Polymorphisms
| Models | Training Bal.Acc. | Testing Bal.Acc. | Sign test (p) | CVC | Chi-Square |
|---|---|---|---|---|---|
| GSTM1 null deletion | 0.6107 | 0.6093 | 3.418E-06 | 9/10 | 21.4596 |
| GSTM1 null deletion+rs1799895 | 0.6343 | 0.6343 | 3.429E-08 | 10/10 | 42.4296 |
| GSTM1 null deletion+rs1051730+rs1799895 | 0.6457 | 0.6052 | 8.472E-10 | 10/10 | 63.4422 |
| GSTM1 null deletion+rs1051730+rs16969968+rs1799895 | 0.6512 | 0.6142 | 1.198E-09 | 9/10 | 77.8238 |
Note: The best model speculated by MDR is composed of GSTM1 null deletion, rs1051730, rs16969968, and rs1799895.
Abbreviations: Training Bal. ACC, Training Balanced Accuracy; Testing Bal. ACC, Testing Balanced Accuracy; CV, Cross Validation Consistency.