Table 6.
Cumulative Effect of Best Models of Gene–Gene Interactions on COPD
| Gene x Gene | Case N = 181 | Control N = 292 | cOR | 95% CI | P value | aOR | 95% CI | P value | ||
|---|---|---|---|---|---|---|---|---|---|---|
| Two-way model | GSTM1 (Null deletion) | RERI = 1.938; AP = 0.289; S = 1.514; SIA = 1.406; M=0.811 | ||||||||
| SOD3 (rs1799895) | C/C | Non null | 45 (0.249) | 151 (0.517) | 1 | – | – | 1 | – | – |
| Null | 75 (0.414) | 95 (0.326) | 2.65 | 1.69–4.15 | <0.001 | 2.24 | 1.32–3.82 | 0.0408 | ||
| Non C/C | Non null | 27 (0.149) | 29 (0.099) | 3.12 | 1.68–5.81 | 0.0003 | 2.84 | 1.36–5.92 | 0.001* | |
| Null | 34 (0.188) | 17 (0.058) | 6.71 | 3.43–13.12 | <0.001 | 6.50 | 2.89–14.64 | <0.001* | ||
| Three-way model (GSTM1 null deletion, rs1051730 and rs1799895) | ||||||||||
| Number of risk genotypes | RERI = 11.58; AP = 0.623; S = 2.925; SIA = 2.651; M = 1.695 | |||||||||
| 0 | 34 (0.188) | 115 (0.394) | 1 | – | – | 1 | – | – | ||
| 1 | 73 (0.403) | 141 (0.483) | 1.75 | 1.09–2.82 | 0.0191 | 1.47 | 0.84–2.57 | 0.2191 | ||
| 2 | 63 (0.348) | 34 (0.116) | 6.27 | 3.56–11.04 | <0.001 | 6.25 | 3.51–11.12 | <0.001* | ||
| 3 | 11 (0.061) | 2 (0.007) | 18.6 | 3.93–88.03 | <0.001 | 17.46 | 3.64–83.72 | 0.0003* | ||
| Four-way model (GSTM1 null deletion, rs1051730, rs16969968 and rs1799895) | ||||||||||
| Number of risk genotypes | RERI = 19.75; AP = 0.483; S = 2.085; M = 0.363 | |||||||||
| 0 | 23 (0.127) | 94 (0.322) | 1 | – | – | 1 | – | – | ||
| 1 | 63 (0.348) | 121 (0.414) | 2.13 | 1.23–3.68 | 0.0055 | 2.03 | 1.17–3.53 | 0.2114 | ||
| 2 | 52 (0.287) | 68 (0.233) | 3.13 | 1.75–5.59 | 0.0001 | 2.98 | 1.64–5.39 | 0.0024* | ||
| 3 | 33 (0.183) | 8 (0.028) | 16.86 | 6.88–41.34 | <0.001 | 16.99 | 6.74–42.85 | <0.001* | ||
| 4 | 10 (0.055) | 1 (0.003) | 40.87 | 4.98–335.63 | 0.0006 | 36.01 | 4.34–298.93 | <0.001* | ||
Notes: The values are given as number (frequency). Odds ratio and confidence interval were calculated by logistic regression. Adjusted for age, gender, BMI, education level, occupational exposure of dust, smoking status. *Significance remained after the Bonferroni correction.