Table 7.
Risk Factors | Case Group (n=146) | Control Group (n=208) | cOR | 95% CI | P value | RERI | AP | S | |
---|---|---|---|---|---|---|---|---|---|
Smoking Related Factor | GenoType | ||||||||
Smoking index | GSTM1 gene | ||||||||
1–399 | Non null | 22 | 61 | 1 | – | – | 1.562 | 0.389 | 2.072 |
Null | 26 | 40 | 1.80 | 0.90–3.61 | 0.096 | ||||
≥400 | Non null | 40 | 67 | 1.66 | 0.89–3.09 | 0.114 | |||
Null | 58 | 40 | 4.02 | 2.14–7.57 | <0.001 | ||||
CPD (number) | GSTM1 gene | ||||||||
<20 | Non null | 32 | 84 | 1 | – | – | 4.122 | 0.628 | 3.86 |
Null | 39 | 62 | 1.65 | 0.93–2.92 | 0.085 | ||||
≥20 | Non null | 30 | 44 | 1.79 | 0.97–3.32 | 0.065 | |||
Null | 45 | 18 | 6.56 | 3.32–12.97 | <0.001 | ||||
CHRNA3 gene (rs1051730) | |||||||||
<20 | G/G | 51 | 116 | 1 | – | – | 1.592 | 0.372 | 1.942 |
G/A | 20 | 30 | 1.52 | 0.79–2.92 | 0.213 | ||||
≥20 | G/G | 43 | 45 | 2.17 | 1.28–3.70 | 0.004 | |||
G/A | 32 | 17 | 4.28 | 2.18–8.40 | <0.001 | ||||
SOD3 gene (rs1799895) | |||||||||
<20 | C/C | 54 | 122 | 1 | – | – | 4.078 | 0.634 | 4.015 |
C/G+G/G | 17 | 24 | 1.60 | 0.79–3.22 | 0.1874 | ||||
≥20 | C/C | 38 | 49 | 1.75 | 1.03–2.98 | 0.0385 | |||
C/G+G/G | 37 | 13 | 6.43 | 3.17–13.06 | <0.001 | ||||
ND | CHRNA3 gene (rs1051730) | ||||||||
Low dependence |
G/G | 37 | 86 | 1 | – | – | 1.899 | 0.456 | 2.506 |
G/A | 18 | 28 | 1.49 | 0.74–3.03 | 0.265 | ||||
High dependence |
G/G | 57 | 75 | 1.77 | 1.05–2.96 | 0.031 | |||
G/A | 34 | 19 | 4.16 | 2.11–8.22 | <0.001 | ||||
Age at onset smoking | SOD3 gene (rs1799895) | ||||||||
>16 | C/C | 78 | 141 | 1 | – | – | 5.812 | 0.757 | 7.678 |
C/G+G/G | 37 | 33 | 2.03 | 1.18–3.49 | 0.011 | ||||
≤16 | C/C | 14 | 30 | 0.84 | 0.42–1.69 | 0.63 | |||
C/G+G/G | 17 | 4 | 7.68 | 2.49–23.63 | 0.0004 | ||||
CHRNA3 gene (rs1051730) | |||||||||
>16 | G/G | 78 | 135 | 1 | – | – | 1.538 | 0.474 | 3.175 |
G/A | 37 | 39 | 1.64 | 0.97–2.79 | 0.0662 | ||||
≤16 | G/G | 16 | 26 | 1.07 | 0.54–2.11 | 0.8563 | |||
G/A | 15 | 8 | 3.25 | 1.32–7.99 | 0.0105 | ||||
Smoking status | SOD3 gene (rs1799895) | ||||||||
Never smoker | C/C | 28 | 75 | 1 | – | – | 1.385 | 0.354 | 1.908 |
C/G+G/G | 7 | 9 | 2.08 | 0.71–6.13 | 0.1824 | ||||
Current smoker | C/C | 92 | 171 | 1.44 | 0.87–2.38 | 0.1542 | |||
C/G+G/G | 54 | 37 | 3.91 | 2.14–7.14 | <0.001 |
Notes: The values are given as number (frequency). Odds ratio and confidence interval were calculated by logistic regression.