Table 7.

Possible Interaction of Smoking-Related Factors with GSTM1, CHRNA3, CHRNA5 and SOD3 Genes Polymorphisms in COPD

Risk Factors		Case Group (n=146)	Control Group (n=208)	cOR	95% CI	P value	RERI	AP	S
Smoking Related Factor	GenoType
Smoking index	GSTM1 gene
1–399	Non null	22	61	1	–	–	1.562	0.389	2.072
	Null	26	40	1.80	0.90–3.61	0.096
≥400	Non null	40	67	1.66	0.89–3.09	0.114
	Null	58	40	4.02	2.14–7.57	<0.001
CPD (number)	GSTM1 gene
<20	Non null	32	84	1	–	–	4.122	0.628	3.86
	Null	39	62	1.65	0.93–2.92	0.085
≥20	Non null	30	44	1.79	0.97–3.32	0.065
	Null	45	18	6.56	3.32–12.97	<0.001
	CHRNA3 gene (rs1051730)
<20	G/G	51	116	1	–	–	1.592	0.372	1.942
	G/A	20	30	1.52	0.79–2.92	0.213
≥20	G/G	43	45	2.17	1.28–3.70	0.004
	G/A	32	17	4.28	2.18–8.40	<0.001
	SOD3 gene (rs1799895)
<20	C/C	54	122	1	–	–	4.078	0.634	4.015
	C/G+G/G	17	24	1.60	0.79–3.22	0.1874
≥20	C/C	38	49	1.75	1.03–2.98	0.0385
	C/G+G/G	37	13	6.43	3.17–13.06	<0.001
ND	CHRNA3 gene (rs1051730)
Low dependence	G/G	37	86	1	–	–	1.899	0.456	2.506
	G/A	18	28	1.49	0.74–3.03	0.265
High dependence	G/G	57	75	1.77	1.05–2.96	0.031
	G/A	34	19	4.16	2.11–8.22	<0.001
Age at onset smoking	SOD3 gene (rs1799895)
>16	C/C	78	141	1	–	–	5.812	0.757	7.678
	C/G+G/G	37	33	2.03	1.18–3.49	0.011
≤16	C/C	14	30	0.84	0.42–1.69	0.63
	C/G+G/G	17	4	7.68	2.49–23.63	0.0004
	CHRNA3 gene (rs1051730)
>16	G/G	78	135	1	–	–	1.538	0.474	3.175
	G/A	37	39	1.64	0.97–2.79	0.0662
≤16	G/G	16	26	1.07	0.54–2.11	0.8563
	G/A	15	8	3.25	1.32–7.99	0.0105
Smoking status	SOD3 gene (rs1799895)
Never smoker	C/C	28	75	1	–	–	1.385	0.354	1.908
	C/G+G/G	7	9	2.08	0.71–6.13	0.1824
Current smoker	C/C	92	171	1.44	0.87–2.38	0.1542
	C/G+G/G	54	37	3.91	2.14–7.14	<0.001

Notes: The values are given as number (frequency). Odds ratio and confidence interval were calculated by logistic regression.