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. 2021 Oct 4;13(19):22843–22855. doi: 10.18632/aging.203578

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Copyright: © 2021 Liu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Microarray analysis exposed the regulation of angiogenesis pathway, and gene miRNA-19a-3p might affect the Allicin-induced MI/R protection. (A) The volcano map showed the differently expressed miRNAs by the criteria of |fold change| >2 and P < 0.05 between MI/R and normal controls. (B–C) Functional classification of these differentially expressed genes based on the Gene Ontology (GO). (D) Partial results of the KEGG pathways. (E) The top 10 differentially expressed miRNAs in myocardium Model group compared with the Control group. (F) RT-PCR indicate that MI/R could induce the expression of miR-19a-3p, which can be further modulated by Allicin. (G) RT-PCR revealed that miR-19a-3p has downregulated in mice MI/R specimens compared with matched control tissues. (H) The Kaplan-Meier survival curve was performed to evaluate the diagnostic value of miR-19a- 3p in MI/R. (I) The potential binding site between miR-19a-3p and PIK3CA (PI3K) by Miranda. (J) The expression levels of miR-19a-3p were noticeably down-regulated in PI3K overexpressed macrophages.