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. 2021 Oct 11;13(19):23245–23261. doi: 10.18632/aging.203616

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Copyright: © 2021 Gao and Ren.

This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Selection of hub genes. PPI network was analyzed by cytohubba, a plugin of Cytoscape. A node represents a gene. The genes reduced in NSCLC tissue were shown in green color. The genes increased in NSCLC tissue were shown in red color; at the same time, the genes which down-regulated in A549 by resveratrol were posted in triangles, and the genes which up-regulated by resveratrol were posted in shape “V”. The hub genes with higher scores were demonstrated with larger size.