Table 6. The association between the expression of CENPL and immune biomarker genes in HCC based on TIMER and GEPIA.
| Description | Gene markers | TIMER | GEPIA | ||
| Cor | P-value | Cor | P-value | ||
| CD8+ T cell | CD8A | 0.284 | 8.18E−08 | 0.160 | 2.30E-03 |
| CD8B | 0.209 | 8.84E−05 | 0.093 | 7.50E-02 | |
| T cell (general) | CD2 | 0.282 | 1.03E−07 | 0.130 | 1.40E-02 |
| CD3E | 0.282 | 9.94E−08 | 0.120 | 2.30E-02 | |
| CD3D | 0.288 | 4.89E−08 | 0.120 | 1.70E-02 | |
| CD6 | 0.259 | 1.04E−06 | 0.130 | 1.20E-02 | |
| SH2D1A | 0.271 | 3.36E−07 | 0.140 | 8.00E-03 | |
| TRAT1 | 0.263 | 7.37E−07 | 0.150 | 3.40E-03 | |
| CD3G | 0.323 | 7.76E−10 | 0.250 | 8.2E−07 | |
| B cell | CD19 | 0.293 | 2.96E−08 | 0.230 | 1.2E−05 |
| CD79A | 0.241 | 5.93E−06 | 0.120 | 2.50E-02 | |
| Monocyte | CD86 | 0.412 | 1.50E−15 | 0.270 | 2.4E−07 |
| CD115 (CSF1R) | 0.295 | 2.22E−08 | 0.180 | 4.90E-04 | |
| TAM | CD68 | 0.282 | 9.54E−08 | 0.200 | 9.9E−05 |
| CCL2 | 0.216 | 5.04E−05 | 0.110 | 4.30E-02 | |
| IL10 | 0.284 | 7.94E−08 | 0.150 | 4.60E-03 | |
| M1 Macrophage | IRF5 | 0.478 | 3.86E−21 | 0.440 | 1.1E−18 |
| M2 Macrophage | CD163 | 0.194 | 2.91E−04 | −0.006 | 9.10E−01 |
| VSIG4 | 0.238 | 8.12E−06 | 0.120 | 2.60E−02 | |
| MS4A4A | 0.228 | 1.99E−05 | 0.100 | 5.10E−02 | |
| Neutrophil | S100A12 | 0.000 | 9.99E−01 | −0.023 | 6.60E−01 |
| CEACAM3 | 0.159 | 3.10E−03 | 0.120 | 2.20E−02 | |
| CCR7 | 0.229 | 1.69E−05 | 0.100 | 5.30E−02 | |
| FPR1 | 0.322 | 9.78E−10 | 0.200 | 7.4E−05 | |
| SIGLEC5 | 0.415 | 7.99E−16 | 0.240 | 2.6E−06 | |
| CSF3R | 0.375 | 5.58E−13 | 0.240 | 3.9E−06 | |
| FCAR | 0.196 | 2.42E−04 | 0.094 | 7.20E−02 | |
| FCGR3B | 0.232 | 1.33E−05 | 0.320 | 3.1E−10 | |
| NK | KIR2DL1 | −0.051 | 3.41E−01 | 0.056 | 2.80E−01 |
| KIR2DL3 | 0.253 | 1.89E−06 | 0.200 | 1.50E−04 | |
| KIR2DL4 | 0.184 | 5.92E−04 | 0.200 | 1E−04 | |
| KIR3DL1 | 0.039 | 4.75E−01 | −0.048 | 3.60E−01 | |
| KIR3DL2 | 0.170 | 1.54E−03 | 0.200 | 7.9E−05 | |
| KIR3DL3 | 0.186 | 4.94E−04 | 0.120 | 1.90E−02 | |
| XCL1 | 0.304 | 8.72E−09 | 0.240 | 2.5E−06 | |
| XCL2 | 0.245 | 3.98E−06 | 0.082 | 1.20E−01 | |
| NCR1 | 0.119 | 2.69E−02 | 0.140 | 5.90E−03 | |
| DC | CD11C (ITGAX) | 0.407 | 3.11E−15 | 0.300 | 7.5E−09 |
| HLA-DPA1 | 0.280 | 1.25E−07 | 0.160 | 1.70E−03 | |
| HLA-DRA | 0.309 | 4.38E−09 | 0.190 | 2.10E−04 | |
| HLA-DQB1 | 0.204 | 1.33E−04 | 0.042 | 4.20E−01 | |
| HLA-DPB1 | 0.274 | 2.23E−07 | 0.160 | 1.60E−03 | |
| CCL13 | 0.162 | 2.59E−03 | 0.090 | 8.30E−02 | |
| HSD11B1 | −0.234 | 1.17E−05 | −0.2 | 9.5E−05 | |
| Th1 | TBX21 (T-bet) | 0.171 | 1.39E−03 | 0.072 | 1.70E−01 |
| TNF | 0.334 | 1.92E−10 | 0.230 | 1.2E−05 | |
| STAT1 | 0.434 | 2.76E−17 | 0.390 | 7.2E−15 | |
| STAT4 | 0.296 | 2.20E−08 | 0.240 | 3.1E−06 | |
| Th2 | IL13 | 0.107 | 4.79E−02 | 0.130 | 1.10E-02 |
| GATA3 | 0.326 | 5.59E−10 | 0.210 | 3.6E−05 | |
| STAT5A | 0.386 | 1.04E−13 | 0.340 | 2.1E−11 | |
| STAT6 | 0.231 | 1.50E−05 | 0.280 | 3.3E−08 | |
| Tfh | VSIG4 | 0.241 | 5.98E−06 | 0.120 | 2.60E-02 |
| Th17 | STAT3 | 0.278 | 1.59E−07 | 0.270 | 9.4E−08 |
| Treg | TGFB1 | 0.366 | 2.32E−12 | 0.220 | 1.6E−05 |
| STAT5B | 0.379 | 3.29E−13 | 0.430 | 2.4E−18 | |
| CCR8 | 0.504 | 1.20E−23 | 0.410 | 2.7E−16 | |
| FOXP3 | 0.264 | 6.30E−07 | 0.140 | 5.50E-03 | |
| T-cell exhaustion | TIGIT | 0.367 | 1.89E−12 | 0.230 | 7.2E−06 |
| GZMB | 0.137 | 1.10E−02 | 0.019 | 7.20E−01 | |
| TOX | 0.322 | 9.49E−10 | 0.240 | 5E−06 | |
| TIM-3 (HAVCR2) | 0.414 | 9.94E−16 | 0.250 | 7.3E−07 | |
| LAG3 | 0.278 | 1.46E−07 | 0.140 | 6.90E−03 | |
| CTLA4 | 0.364 | 3.02E−12 | 0.240 | 2.5E−06 | |
| PD-1 (PDCD1) | 0.363 | 3.60E−12 | 0.240 | 2.6E−06 | |
Abbreviations: TAM: tumor-associated macrophage; IL: interleukin; Tfh: follicular helper T cell; TNF: tumor necrosis factor; DC: dendritic cell; Treg: regulatory T cell; TIMER: Tumor Immune Estimation Resource; GEPIA: Gene Expression Profiling Interactive Analysis; NK: natural killer cell; Th: T helper cell; HCC: hepatocellular carcinoma; Cor: R value of Spearman’s correlation; CENPL: centromere protein L.