Table 1. Lifespan results and statistical analysis.
Strains, Compounds | Max lifespan in days ± SD (10th percentile) | Medium lifespan in days ± SD (50th percentile) | Number of experiments (n) | P value versus control | Number of nematodes |
N2 DMSO | 35.7 ± 0.6 | 28.8 ± 0.3 | 18 | 2831 | |
N2 EGCG | 36.9 ± 0.1 | 30.8 ± 0.1 | 18 | <0.0001 | 2842 |
N2 ECG | 37.1 ± 0.3 | 30.6 ± 0.3 | 15 | <0.0001 | 2777 |
N2 BHA | 36.4 ± 0.6 | 28.9 ± 0.4 | 9 | 0.3838 | 1548 |
N2 BHA + EGCG | 36.0 ± 0.3 | 29.2 ± 0.4 | 9 | 0.3114 | 1581 |
N2 BHA + ECG | 35.9 ± 0.5 | 29.6 ± 0.4 | 6 | 0.6682 | 1451 |
aak-2 (ok524) DMSO | 24.2 | 20.9 ± 0.2 | 3 | 462 | |
aak-2 (ok524) EGCG | 24.4 ± 0.2 | 20.5 ± 0.3 | 3 | 0.1015 | 465 |
aak-2 (ok524) ECG | 24.6 ± 0.7 | 20.4 ± 0.4 | 3 | 0.9876 | 452 |
sir-2.1 (ok434) DMSO | 28.6 ± 0.1 | 24.3 ± 0.4 | 3 | 400 | |
sir-2.1 (ok434) EGCG | 28.9 ± 1.2 | 24.5 ± 0.3 | 3 | 0.1858 | 355 |
sir-2.1 (ok434) ECG | 28.2 ± 0.5 | 23.7 ± 0.1 | 3 | 0.24 | 436 |
pmk-1 (km25) DMSO | 34.9 ± 0.6 | 27.9 ± 0.4 | 3 | 548 | |
pmk-1 (km25) EGCG | 35.5 ± 1.5 | 28.2 ± 1.1 | 3 | 0.7759 | 567 |
pmk-1 (km25) ECG | 35.3 ± 0.7 | 28.0 ± 0.3 | 3 | 0.7363 | 581 |
skn-1 (zu67) DMSO | 16.5 ± 0.5 | 14.1 ± 0.1 | 6 | 424 | |
skn-1 (zu67) EGCG | 17.0 ± 0.2 | 14.2 ± 0.1 | 6 | 0.5286 | 432 |
skn-1 (zu67) ECG | 16.8 ± 0.2 | 14.3 | 6 | 0.4823 | 440 |
daf-16 (mgDF47) DMSO | 22.5 ± 0.3 | 20.1 ± 0.1 | 3 | 660 | |
daf-16 (mgDF47) EGCG | 22.2 ± 0.2 | 19.8 | 3 | 0.029 | 774 |
daf-16 (mgDF47) ECG | 21.7 ± 0.6 | 19.4 ± 0.2 | 3 | <0.0001 | 707 |
sod-2 (gk257) DMSO | 33.3 ± 0.4 | 27.2 ± 0.4 | 3 | 730 | |
sod-2 (gk257) EGCG | 33.1 ± 0.4 | 27.5 ± 0.4 | 3 | 0.9525 | 788 |
ctl-2 (ok1137) DMSO | 32.5 ± 0.4 | 26.8 ± 0.7 | 3 | 602 | |
ctl-2 (ok1137) ECG | 32.9 ± 0.5 | 27.2 ± 0.4 | 3 | 0.1718 | 614 |