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. 2021 Oct 15;9(10):1376. doi: 10.3390/healthcare9101376

Figure 4.

Figure 4

Effect of St. John’s wort (SJW) extract and hyperforin (HF) on estrogen receptor levels in MCF-7 cells. The luciferase activities in MCF-7 cells transfected with ERα (a,c) or ERβ (b,d) were measured after treatment with 0.2 to 20 µg/mL SJW extract (a,b) or 10−5 to 10 µM HF (c,d). A positive control was prepared by treating the cells with 10−2 µM 17β-E2. Bars represent the averages of triplicate determinations. * p < 0.05 and *** p < 0.001. Reprinted from Kwon, J.; Oh K.S.; Cho, S.Y.; Bang, M.A.; Kim, H.S.; Vaidya, B.; Kim, D. Estrogenic Activity of Hyperforin in MCF-7 Human Breast Cancer Cells Transfected with Estrogen Receptor. Planta Med. 2016, 82, 1425–1430, with STM permission © Georg Thieme Verlag KG. Any further reuse will need explicit permission from publisher [58].