Table 2.
Information of the analyzed LGR4 SNPs in this study.
| SNP | Physical position | Locationand function | Allele change | Amino acid change | HWEp | MAF in dbSNP | MAF in this study |
|---|---|---|---|---|---|---|---|
| rs2447995 | 27388910 | 3’-UTR | T>C | NA | 0.53 | 0.15 | 0.14 |
| rs1531557 | 27392574 | Intron | C>T | NA | 0.73 | 0.13 | 0.11 |
| rs10835171 | 27398845 | Intron | A>G | NA | 0.20 | 0.44 | 0.45 |
| rs10835173 | 27401190 | Intron | A>G | NA | 0.68 | 0.40 | 0.48 |
| rs11029986 | 27401389 | Intron | C>T | NA | 1.0 | 0.12 | 0.04 |
| rs6484295 | 27406844 | synon codon | G>A | S191S | 0.14 | 0.43 | 0.42 |
| rs2219783 | 27411298 | Intron | A>G | NA | 0.71 | 0.09 | 0.07 |
| C376T | 27412666 | nonsense mutant | G/G | / | 1.0 | / | 0.0 |
| rs7936621 | 27426391 | Intron | G>A | NA | 1.0 | 0.29 | 0.30 |
| rs12787344 | 27428264 | Intron | C>A | NA | 0.08 | 0.13 | 0.19 |
| rs7927234 | 27436356 | Intron | G>C | NA | 0.87 | 0.04 | 0.08 |
| rs4128868 | 27444517 | Intron | T>C | NA | 0.11 | 0.21 | 0.26 |
| rs4514364 | 27456059 | Intron | T>C | NA | 0.21 | 0.22 | 0.25 |
| rs4074516 | 27465591 | Intron | T>C | NA | 0.30 | 0.48 | 0.45 |
| rs4923445 | 27471596 | Intron | A>G | NA | 0.81 | 0.20 | 0.22 |
| rs4542364 | 27473981 | Intron | A>G | NA | 1.0 | 0.32 | 0.40 |
| rs11030014 | 27480827 | Intron | T>C | NA | 0.13 | 0.09 | 0.18 |
| rs16917037 | 27483834 | Intron | G>A | NA | 0.96 | 0.22 | 0.21 |
| rs11030016 | 27487992 | Intron | T>C | NA | 1.0 | 0.44 | 0.46 |
| rs12796247 | 27494625 | Intron | C>T | NA | 0.74 | 0.37 | 0.37 |
| rs4923447 | 27495259 | Intron | T>C | NA | 0.53 | 0.13 | 0.16 |
| rs10835187 | 27505677 | / | T>C | NA | 0.95 | 0.46 | 0.42 |
NA, not applicable; SNP, single-nucleotide polymorphism; HWE, Hardy-Weinberg equilibrium; MAF, minor allele frequency.