Table 3.
QTDT results regarding the associations between the single nucleotide polymorphisms and phenotypic variations.
| Genotype | rs2447995 | rs10835171 | rs10835173 | rs6484295 | rs7936621 | rs12787344 | rs4128868 | rs4074516 | rs4542364 | rs11030014 | rs16917037 | rs4923447 | rs10835187 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Test of population stratification | |||||||||||||
| Femoral neck BMD | 0.707 | 0.892 | 0.758 | 0.880 | 0.972 | 0.661 | 0.398 | 0.048 | 0.317 | 0.062 | 0.896 | 0.247 | 0.477 |
| Total hip BMD | 0.649 | 0.839 | 0.832 | 0.949 | 0.445 | 0.522 | 0.877 | 0.139 | 0.721 | 0.148 | 0.947 | 0.292 | 0.657 |
| Lumbar spine BMD | 0.295 | 0.668 | 0.359 | 0.869 | 0.141 | 0.693 | 0.470 | 0.112 | 0.313 | 0.040 | 0.207 | 0.048 | 0.231 |
| TFM | 0.635 | 0.233 | 0.718 | 0.564 | 0.945 | 0.674 | 0.731 | 0.740 | 1.000 | 0.553 | 0.691 | 0.041 | 0.073 |
| TLM | 0.801 | 0.508 | 0.598 | 0.821 | 0.662 | 0.725 | 0.641 | 0.315 | 0.676 | 0.491 | 0.525 | 0.098 | 0.563 |
| PFM | 0.661 | 0.496 | 0.990 | 0.863 | 0.686 | 0.511 | 0.896 | 0.652 | 0.973 | 0.546 | 0.962 | 0.013 | 0.040 |
| PLM | 0.632 | 0.258 | 0.632 | 0.503 | 0.992 | 0.784 | 0.822 | 0.623 | 0.713 | 0.647 | 0.735 | 0.017 | 0.030 |
| Trunk fat mass | 0.557 | 0.164 | 0.528 | 0.412 | 0.600 | 1.000 | 0.448 | 0.774 | 9.00E-29 | 0.621 | 0.387 | 0.088 | 0.050 |
| BMI | 0.927 | 0.118 | 0.265 | 0.264 | 0.668 | 0.888 | 0.513 | 0.912 | 0.417 | 0.512 | 0.233 | 0.703 | 0.194 |
| Tests for total association | |||||||||||||
| Femoral neck BMD | 0.189 | 0.684 | 0.669 | 0.722 | 0.003 | 0.025 | 0.025 | 0.927 | 0.750 | 0.011 | 0.037 | 0.165 | 0.032 |
| Total hip BMD | 0.381 | 0.994 | 0.897 | 0.525 | 0.013 | 0.068 | 0.066 | 0.816 | 0.775 | 0.024 | 0.195 | 0.113 | 0.015 |
| Lumbar spine BMD BMD | 0.969 | 0.836 | 0.899 | 0.718 | 0.058 | 0.109 | 0.208 | 0.570 | 0.269 | 0.037 | 0.169 | 0.470 | 0.084 |
| TFM | 0.569 | 0.316 | 0.487 | 0.224 | 0.867 | 0.576 | 0.813 | 0.121 | 0.637 | 0.907 | 0.855 | 0.883 | 0.790 |
| TLM | 0.193 | 0.350 | 0.403 | 0.157 | 0.272 | 0.333 | 0.199 | 0.497 | 0.647 | 0.146 | 0.630 | 0.641 | 0.591 |
| PFM | 0.766 | 0.494 | 0.806 | 0.469 | 0.633 | 0.235 | 0.748 | 0.196 | 0.552 | 0.783 | 0.941 | 0.715 | 0.974 |
| PLM | 0.827 | 0.372 | 0.647 | 0.400 | 0.944 | 0.542 | 0.892 | 0.283 | 0.762 | 0.856 | 0.983 | 0.898 | 0.919 |
| Trunk fat mass | 7.00E-29 | 0.208 | 7.00E-29 | 0.135 | 9.00E-29 | 0.747 | 9.00E-29 | 0.223 | 1.000 | 9.00E-29 | 0.7162 | 0.805 | 0.623 |
| BMI | 0.389 | 0.230 | 0.377 | 0.131 | 0.431 | 0.778 | 0.382 | 0.106 | 0.704 | 0.813 | 0.738 | 0.673 | 0.993 |
| Test for within-family association | |||||||||||||
| Femoral neck BMD | 0.521 | 0.829 | 0.914 | 0.713 | 0.031 | 0.157 | 0.258 | 0.166 | 0.647 | 0.618 | 0.096 | 0.071 | 0.311 |
| Total hip BMD | 0.772 | 0.899 | 0.964 | 0.658 | 0.020 | 0.071 | 0.137 | 0.245 | 0.968 | 0.563 | 0.346 | 0.061 | 0.159 |
| Lumbar spine BMD BMD | 0.434 | 0.662 | 0.600 | 0.867 | 0.017 | 0.140 | 0.155 | 0.518 | 0.915 | 0.982 | 0.062 | 0.059 | 0.691 |
| TFM | 0.458 | 0.124 | 0.454 | 0.193 | 0.892 | 0.485 | 0.681 | 0.177 | 0.720 | 0.740 | 0.704 | 0.130 | 0.263 |
| TLM | 0.481 | 0.255 | 0.331 | 0.222 | 0.276 | 0.337 | 0.205 | 0.847 | 0.968 | 0.591 | 0.436 | 0.136 | 0.430 |
| PFM | 0.601 | 0.336 | 0.863 | 0.508 | 0.533 | 0.183 | 0.743 | 0.209 | 0.683 | 0.536 | 0.930 | 0.047 | 0.141 |
| PLM | 0.618 | 0.157 | 0.509 | 0.283 | 0.954 | 0.522 | 0.802 | 0.262 | 0.973 | 0.653 | 0.815 | 0.080 | 0.144 |
| Trunk fat mass | 6.00E-29 | 0.063 | 6.00E-29 | 0.094 | 8.00E-29 | 0.767 | 7.00E-29 | 0.348 | 0.829 | 1.00E-28 | 0.395 | 0.199 | 0.270 |
| BMI | 0.515 | 0.052 | 0.159 | 0.061 | 0.392 | 0.762 | 0.278 | 0.271 | 0.767 | 0.760 | 0.296 | 0.570 | 0.356 |
| P1000 permutation of within-family | |||||||||||||
| Femoral neck BMD | 0.487 | 0.837 | 0.923 | 0.740 | 0.038 | 0.157 | 0.297 | 0.175 | 0.610 | 0.597 | 0.064 | 0.097 | 0.341 |
| Total hip BMD | 0.733 | 0.908 | 0.960 | 0.691 | 0.029 | 0.080 | 0.157 | 0.271 | 0.965 | 0.576 | 0.312 | 0.105 | 0.174 |
| Lumbar spine BMD BMD | 0.437 | 0.677 | 0.602 | 0.859 | 0.031 | 0.139 | 0.191 | 0.519 | 0.924 | 0.985 | 0.054 | 0.071 | 0.695 |
| TFM | 0.537 | 0.127 | 0.466 | 0.168 | 0.963 | 0.470 | 0.680 | 0.237 | 0.761 | 0.795 | 0.757 | 0.147 | 0.366 |
| TLM | 0.484 | 0.265 | 0.354 | 0.261 | 0.362 | 0.380 | 0.269 | 0.877 | 0.957 | 0.591 | 0.404 | 0.215 | 0.411 |
| PFM | 0.618 | 0.309 | 0.862 | 0.478 | 0.458 | 0.104 | 0.675 | 0.227 | 0.711 | 0.534 | 0.930 | 0.056 | 0.135 |
| PLM | 0.628 | 0.117 | 0.462 | 0.244 | 0.933 | 0.448 | 0.770 | 0.263 | 0.973 | 0.643 | 0.821 | 0.067 | 0.138 |
| Trunk fat mass | 0.279 | 0.045 | 0.233 | 0.064 | 0.452 | 0.802 | 0.382 | 0.328 | 0.877 | 0.845 | 0.392 | 0.155 | 0.292 |
| BMI | 0.537 | 0.050 | 0.165 | 0.043 | 0.394 | 0.739 | 0.267 | 0.325 | 0.792 | 0.797 | 0.317 | 0.600 | 0.401 |
Bold indicates a significant P-value (<0.05).