Table 1.

Summary of various drugs and inhibitors delivered by polysaccharide-based hydrogels DDSs.

	Polymer Name	Polysaccharides and Additives	Delivered Molecule	Functions of Polysaccharides	Year	References
Genes	siRNA-loaded microgels	Cationic biodegradable dextran microgels	siRNA	Increase encapsulation amount, Controlled release of materials	2008	[74]
	Folate conjugated nanogel	Glycol chitosan-based nanogel	siRNA	Improve delivery of material	2013	[75]
	Plasmid DNA-loaded nanogel	CMC complex with bPEI nanogel	Plasmid DNA	Improve delivery of materials, Increase uptake and gene transfection	2015	[76]
	Double-network nanogels	Silane-crosslinked PEI with pH-responsive poly(2-(hexamethyleneimino)ethyl methacrylate)	DNA	pH-responsive delivery, Improve stability of genetic material	2019	[77]
	TAC6-derived nanogel	TAC6 polymer	PIAS1	Decrease gut inflammation by repressing NF-KB	2020	[78]
	Nanobody-functionalized nanogel	Nanobody conjugated DNA strands with Nb-DNA conjugate	miRNA	Increase accumulation of miRNA to desired site, Increase anti-tumor effect	2020	[79]
Peptides and Proteins	Hydrophillic thermo-responsive nanogels	NIPAM, poly(N-Isopropylmethacrylamide)	Protein	High protein encapsulation, Release protein at desired temperature	2019	[80]
	Nisin-loaded antimicrobial dual responsive nanogel	PLLA-g-CS	Peptide	Release nisin at specific pH and temperature	2019	[81]
	CytoC-embedded hydrogel	Acrylamide (AAm), 2-(dime- thylamino)ethyl methacrylate (DMAEMA) monomer and glycerol dimethacrylate (GDA)	Protein	Promoted delivery of CytoC to target sites, Improve tumor growth inhibition	2020	[82]
	pH and glucose dual-responsive nanogels	Dextran and poly(L-glutamic acid)-g-methoxy poly-(-ethylene glycol)/phenyl boronic acid (PLG-g-mPEG/PBA)	Protein	Mediates the delivery and release of protein	2019	[83]
	Temperature-sensitive nanogel	PEG, N-cyclopropylacrylamide (NCPAM), N-isopropylacrylamide (NIPAM), methacrylic acid (MAA) and trimethylsilylpropargylmethacrylate (TMSPMA)	Protein	Mediates the release of protein when triggered by enzyme and at specific temperature	2020	[84]
	Acid-degradable nanogels	Carboxymethyl chitosan	DOX	Decrease degradation of drug, improve cellular uptake of drug, improve stability of drug in physiological conditions	2019	[85]
Drugs	Hyaluronic acid nanogel	Hyaluronic acid, sucrose, glycerol diglycidyl ether (GDE)	[3-((E)-3-(4-hydroxyphenyl) acryloil)-2H-chromen-2-on	Improve delivery of drug, improve long-term delivery of drug	2019	[86]
	Zwitterionic phosphorylcholine-based nanogel	Poly(phosphorylcholine) (HPMPC)	DOX	Longer blood circulation of nanogel, improve tumor inhibition, effective degradability to release drug to desired site	2021	[87]
	Zwitterionic phosphorylcholine-based nanogel Ca2+ responsive deacetylated gellan gum based in situ-nanogel	Poly(phosphorylcholine) (HPMPC) Deacetylated gellan gum (DGG)	DOX Harmine nanocrystals (HAR-NC)	Able to deliver drugs passing through BBB, release drug in hypoxic environment	2021	[88]
				Improve intranasal drug delivery, increase bioavailability of drug in brain,	2021	[89]
	Chitosan-polypyrrole nanogels	Chitosan, pyrrole	DOX	Highly adaptive to surrounding pH, compatible at physiological pH, high loading of drug, prolonged circulation, increase tumor accumulation of nanogel	2021	[90]
	Tumor microenvironment (TME)-responsive P(CPT-MAA) prodrug nanogel	Methacrylic acid (MAA), CPT monomer (CTPM), and N-N’-methylenebisacrylamide (Bis)	Campthothecin (CPT)	Improve drug delivery, releases drug at specific conditions	2019	[91]
	Supramolecular polymer nanogel	Hyperbranced polyglycerol, polyglycerylamine, carboxylic-substituted copillar[5]arene, carbonyldiimidazole, sodium 6-chlorohexyl sulfate, DMF and triethylamine	Dexamethasone	Increase drug loading capacity, improve skin penetration	2019	[92]
	Hybrid bovine serum albumin-gum arabic aldehyde (BSA-GAA) nanogels	Gum arabic aldehyde, bovine serum albumin	5-FU	Increase drug release at acidic pH, no toxicity of drug when loaded into nanogel	2021	[93]