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. 2021 Oct 11;13:735524. doi: 10.3389/fnagi.2021.735524

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Copyright © 2021 Kotredes, Oblak, Pandey, Lin, Garceau, Williams, Uyar, O’Rourke, O’Rourke, Ingraham, Bednarczyk, Belanger, Cope, Foley, Logsdon, Mangravite, Sukoff Rizzo, Territo, Carter, Sasner, Lamb and Howell.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Age is primary factor driving increases in measures of frailty. Cross-sectional cohorts of young and old mice inspected for measures of physical well-being, or frailty (A,B), including body weight (C,D). Post-mortem, non-fasted, blood biochemistry analysis provided serum levels of cholesterol, lipoproteins, lipids, and glucose (E–L). Age-dependent differences within genotype and sex determined by two-way ANOVA. Factor effects and effect interaction displayed in tables. *p < 0.05; **p < 0.01; ***p < 0.001. All alleles expressed were homozygous.