Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Oct 11;13:735524. doi: 10.3389/fnagi.2021.735524

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Kotredes, Oblak, Pandey, Lin, Garceau, Williams, Uyar, O’Rourke, O’Rourke, Ingraham, Bednarczyk, Belanger, Cope, Foley, Logsdon, Mangravite, Sukoff Rizzo, Territo, Carter, Sasner, Lamb and Howell.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Increases in regional glucose metabolism due to expression of APOE4 and Trem2*R47H. Positron emission tomography (PET; red scale) of radioactive 18F-FDG marker was used to measure tissue glucose uptake, guided by computed tomography (CT; black and white) mapping to brain regions of interest, indicated by bregma coordinates (far left) (A). PET-CT of 64-Cu PTSM of female and male B6.APOE4.Trem2*R47H mice revealed age-driven increases in brain perfusion (B). Post-mortem autoradiography of coronal brain tissue is represented in (A) (rainbow; far right). Genotype- and age-dependent differences determined by three-way ANOVA. Factor effects and effect interaction are displayed in tables. *p < 0.05; **p < 0.01; ***p < 0.001. All alleles expressed were homozygous.