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. 2021 Oct 11;13:735524. doi: 10.3389/fnagi.2021.735524

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Copyright © 2021 Kotredes, Oblak, Pandey, Lin, Garceau, Williams, Uyar, O’Rourke, O’Rourke, Ingraham, Bednarczyk, Belanger, Cope, Foley, Logsdon, Mangravite, Sukoff Rizzo, Territo, Carter, Sasner, Lamb and Howell.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Levels of immunomodulatory cytokines in plasma are significantly different due to increased age and combined expression of APOE4 and Trem2*R47H alleles. IFN-gamma (IFN-γ), IL-1beta, IL-10, IL-6, and KC/GRO (CXCL1) levels were measured by multiplex immunoassays of blood plasma from C57BL/6J and B6.APOE4.Trem2R47H mice (A–F). Genotype- and age-dependent differences determined by two-way ANOVA. Factor effects displayed in tables. *p < 0.05; **p < 0.01; ***p < 0.001. All alleles expressed were homozygous.