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. 2021 Oct 11;13:735524. doi: 10.3389/fnagi.2021.735524

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Copyright © 2021 Kotredes, Oblak, Pandey, Lin, Garceau, Williams, Uyar, O’Rourke, O’Rourke, Ingraham, Bednarczyk, Belanger, Cope, Foley, Logsdon, Mangravite, Sukoff Rizzo, Territo, Carter, Sasner, Lamb and Howell.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Neuropathological analysis of cortex and hippocampus. Hematoxylin and eosin (H&E), luxol fast blue/cresyl violet (LFB/CV), and Prussian blue staining tissue staining protocols (A) to identify anatomical changes in the cortex and hippocampus of young and aged mice. Thioflavin S (Thios) and four combinations of known neuropathological markers of LOAD in aged mice, 5xFAD included as amyloidogenic positive control (B). Neuropathological analysis of cortex and hippocampus. Neuron (NeuN) cell populations were quantified in panel (C). Age- and genotype-dependent differences determined by two-way ANOVA. Factor effects and effect interaction displayed in tables. *p < 0.05; **p < 0.01; ***p < 0.001. All alleles expressed were homozygous.