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. 2021 Oct 11;13:735524. doi: 10.3389/fnagi.2021.735524

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Copyright © 2021 Kotredes, Oblak, Pandey, Lin, Garceau, Williams, Uyar, O’Rourke, O’Rourke, Ingraham, Bednarczyk, Belanger, Cope, Foley, Logsdon, Mangravite, Sukoff Rizzo, Territo, Carter, Sasner, Lamb and Howell.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Overview of brain transcriptome. Expression levels of mouse Apoe (A), human APOE (B), and mouse Trem2 (C) genes in the B6.APOE4, B6.Trem2*R47H, B6.APOE4.Trem2*R47H and C57BL/6J mice at 4, 8, 12, and 24 months in both sexes. Principal component analysis (PCA) of RNA-Seq transcriptomics data from all 234 samples (D). The percent of variation explained by each principal component is displayed on the corresponding axis. Female and male samples are represented as circles and triangles, respectively. Genotypes are shown by different colors and the increasing size of points correspond to the increasing age of mice (4, 8, 12, and 24 months respectively). All alleles expressed were homozygous.