Table 1.

List of functionally validated cellular microRNAs that regulate PARP-1mRNA in the context of human diseases.

miRNA	Functional Assay	Region	Disease Relevance/Context	Ref.
miR-181a	Gof/Lof	3′-UTR	Acute Myeloid Leukemia	[61]
miR-7-5p	Gof/Lof; Reporter assay	3′-UTR	Small cell lung cancer	[62]
miR-379-5p	Luciferase Reporter assay	3′-UTR	Premature ovarian insufficiency	[63]
miR-103a-2-5 pmiR-585-5p	Luciferase Reporter assay	ORF	Oxidative stress, Hypertension	[64]
miR-335	Luciferase Reporter assay	3′-UTR	Small cell lung cancer	[65]
miR-520	Luciferase Reporter assay	3′-UTR	Recurrent spontaneous abortion	[66]
miR-223	Gof/Lof; Reporter assay	3′-UTR	Pulmonary arterial hypertension	[67]
miR-489	Luciferase Reporter assay	3′-UTR	Ischemic kidney injury	[68]
Let-7a	Luciferase Reporter assay	3′-UTR	HER2-overexpressing Breast cancer	[69]
miR-149	Luciferase Reporter assay	3′-UTR	Skeletal muscle metabolism	[16]
miR-577	Luciferase Reporter assay	3′-UTR	Myocardial infarction	[70]
miR-221-3p	Luciferase Reporter assay	3′-UTR	Triple negative Breast cancer	[61]
miR-124	Gof/Lof; Reporter assay, RNA-pulldown	3′-UTR	Drug (cocaine) abuse	[52]
miR-125b	Gof/Lof; Reporter assay, RNA-pull-down	3′-UTR	Drug (cocaine) abuse; Regulation of HIV integration	[53,71]

Abbreviations used: Gof/Lof, gain-of-function/loss-of-function; 3′-UTR, 3′-untranslated region; ORF, open reading frame.