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. 2021 Sep 30;6(4):180. doi: 10.3390/tropicalmed6040180

Figure 1.

Figure 1

Genome Structure and Organization of the Dengue Virus. The dengue virus is spherical in shape, enveloped, and contains a positive-sense, single-stranded RNA genome. The genome encodes a precursor polyprotein, with an open-reading frame ~11 kb in length. Following viral entry into the host cell, the polyprotein is cleaved into three structural proteins (capsid, pre-membrane, and envelope), and seven nonstructural proteins (NS1, NS2A, NS2B, NS3, NS4A with a 2k signal peptide at the C-terminal, NS4B, and NS5).