Table 1.

Small Molecule Inhibitors against dengue NS3 and NS5.

Target	Function	PDB ID	Compound Name	Ki or KD (μM)	IC50 (μM)	References
NS5	MTase	3P8Z	Compound 10	0.82 (N7), 0.17 (2′-O)	na	[73]
		1R6A	Ribavirin 5′-triphosphate	55 *	100	[74]
		5EHI	BF287	na	452	[75]
		5EKX	NB2E11	na	>1000	[75]
		5EHG	BF341	na	369	[75]
		5EIF	NB2C3	na	>1000	[75]
		5EC8	BF175	na	na	[75]
		5EIW	NB3C2	na	>1000	[75]
		5E9Q	BF174	na	na	[75]
		4R8S	Sinefungin	0.136 *	0.03 (N7), 0.04 (2′-O)	[76,77,78]
		na	1-TP	22	8.4	[79]
		na	2-TP	na	1.1	[79]
	RdRp	5K5M	Compound 27	na	0.173	[80]
		5I3P	Compound 27	na	0.048	[80]
		5I3Q	Compound 29	na	0.016	[80]
		5IQ6	HeE1-2Tyr	1.96	1.5	[81]
		5HMW	Compound 5	154 *	177	[82]
		5HMY	Compound 15	1.4 *	1.7	[82]
		6IZX	RK-0404678	na	201	[83]
		5HMX	Compound 10	28 *	15	[82]
		5HN0	Compound 4	>200 *	769	[82]
		5HMZ	Compound 23	0.12 *	0.34	[82]
		3VWS	NITD-107	225 *	113	[84]
		5F3Z	PC-79-SH52	29 *	140	[85]
		5F3T	JF-31-MG46	210	730	[85]
		5F41	FD-83-KI26	67 *	210	[85]
		6IZZ	RK-0404678	na	287	[83]
NS3	Protease (NS2B-NS3)	4M9T	DTNB	na	na	[86]
		3U1J	Aprotinin	0.026	na	[87,88]
		6MO1	Compound 8	na	0.29	[89]
		6MO2	Compound 9	na	0.59	[89]

IC₅₀—Half maximal inhibitory concentration; K_i—inhibition constant; K_D—dissociation constant; * indicates the value shown is a K_D; PDB—protein data bank.