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. Author manuscript; available in PMC: 2022 Nov 1.
Published in final edited form as: J Immunol. 2021 Nov 1;207(9):2205–2215. doi: 10.4049/jimmunol.2100565

Fig 2: Major sources of IL-10 and its responses, common to both mice and humans.

Fig 2:

Various immune and non-immune cells, as indicated in the top panel, are known to produce IL-10 in mice and humans. Additionally, viruses also carry the homolog of IL-10. Regardless of cellular sources, IL-10 can act only on cells expressing the IL-10 receptor consisting of both IL-10R1 and IL-10R2 components, as shown in the bottom panel. The table within the circle shows major functions of IL-10 mediated by the cell types shown for each function.