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ABS probes for biological copper detection: (a) biomimetic CuI–O2 activation, followed by C–O cleavage to release fluorophore;4,94 (b) CuII-catalyzed hydrazide hydrolysis;42 (c) monitoring copper levels in the mitochondria (RdlTPA-TPP;95 adapted from ref 95. Copyright 2014 Royal Society of Chemistry); (d) monitoring labile CuI levels in a diet-induced mouse model of NAFLD (CCL-1;4 adapted from ref 4. Copyright 2016 PNAS).
