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. 2021 Feb 10;6(1):e00819-20. doi: 10.1128/mSphere.00819-20

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Copyright © 2021 Lau et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 3 — Estimation of the tMRCA of bat 229E-related CoVs, camel 229E-related CoVs, alpaca 229E-related CoVs, and HCoV-229E. The time-scaled phylogeny was summarized from MCMC phylogeny of the complete ORF1ab sequence data analyzed using the uncorrelated exponential relaxed clock and exponential growth coalescent model with an exponential distribution in BEAST v 1.8.2. The HCoV-229E strain from the COVID-19 fatal case is marked with a triangle and an arrow. The different genogroups of HCoV-229E are indicated by different colors: fuchsia, HCoV-229E genogroup 3; blue, HCoV-229E genogroup 4; purple, HCoV-229E genogroup 5; red, HCoV-229E genogroup 6. Country codes are as follows: DEU, Germany; GHA, Ghana; HKG, Hong Kong; HTI, Haiti; KEN, Kenya; KSA, Kingdom of Saudi Arabia; ITA, Italy; NLD, The Netherlands; USA, United States.