TABLE 2.
Orthologs of glycolipid biosynthetic genes
| Chemical precursora |
Biosynthetic enzyme (reference geneb) |
S. mitis ATCC 49456 |
S. oralis ATCC 35037 |
Streptococcus sp. 1643 |
S. pneumoniae TIGR4 |
||||
|---|---|---|---|---|---|---|---|---|---|
| Locus tag | AAc | Locus tag | AA | Locus tag | AA | Locus tag | AA | ||
| UDP-Glc | α-Phosphoglucomutase (pgm) (44) |
SM12261_RS05265 | 98.6 | HMPREF8579_1344 | 97.0 | FD735_RS05500 | 97.2 | SP_1498 | 100.0 |
| UTP: α-glucose-1-phosphate uridyltransferase (galU) (44) |
SM12261_RS05330 | 95.3 | HMPREF8579_0527 | 93.7 | FD735_RS00655 | 93.7 | SP_2092 | 95.7 | |
| UDP-Gal | Galactokinase (galK) (46) | SM12261_RS02220 | 97.2 | HMPREF8579_1824 | 95.7 | FD735_RS02200 | 97.0 | SP_1853 | 97.5 |
| Galactose-1-phosphate uridyltransferase 2 (galT2) (46) |
SM12261_RS02225 | 94.9 | HMPREF8579_1822 | 93.1 | FD735_RS02210 | 92.3 | SP_1852 | 96.2 | |
| Glc-DAG | Glycosyltransferase (spr0982) (47) |
SM12261_RS04480 | 96.6 | HMPREF8579_1104 | 88.4 | FD735_RS04125 | 88.6 | SP_1076 | 99.3 |
| Gal-Glc-DAG | Glycosyltransferase (cpoA) (48) |
SM12261_RS04475 | 97.4 | HMPREF8579_1103 | 87.0 | FD735_RS04120 | 87.3 | SP_1075 | 99.7 |
a
Abbreviations: UDP, uridine diphosphate; Glc, glucose (glucosyl); Gal, galactose (galactosyl); DAG, diacylglycerol.
b
S. pneumoniae R6 gene was used as the reference.
c
Percentage of amino acid sequence identity to the referenced enzyme.